Document Detail

Flavonoid intake and liver cancer: a case-control study in Greece.
MedLine Citation:
PMID:  18350370     Owner:  NLM     Status:  MEDLINE    
In the context of a case-control study undertaken in Greece, we examined the role of six flavonoid classes in the etiology of hepatocellular carcinoma (HCC), by viral status, and of cholangiocarcinoma (CAC). Data and blood samples were collected between 1995 and 1998. Information about dietary intakes and covariates, including chronic infection with hepatitis B (HBV) and C (HCV) virus, were available for 250 HBV and/or HCV positive HCC cases, 83 HBV and HCV negative HCC cases, six CAC cases, and 360 hospital controls. In logistic regression models including gender, age, education, tobacco smoking, and total energy intake, there were no distinct patterns with respect to either HCC virus positive and HCC virus negative in relation to total flavonoids or any class of flavonoids, with the exception of flavones. Flavone intake, mostly derived from spinach and peppers, was inversely associated with both virus positive (P-trend, 0.049) and virus negative (P-trend, 0.084) HCC. There was also a suggestion of an inverse association of CAC with flavan-3-ols, anthocyanidins, and total flavonoids which, however, has to be taken with due caution on account of the small number of cases of this rare tumor. We conclude that flavones may be inversely associated with HCC risk, irrespective of its dominant etiology (viral or non viral).
Pagona Lagiou; Marta Rossi; Areti Lagiou; Anastasia Tzonou; Carlo La Vecchia; Dimitrios Trichopoulos
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2008-03-19
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  19     ISSN:  1573-7225     ISO Abbreviation:  Cancer Causes Control     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2009-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  813-8     Citation Subset:  IM    
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, 75 M. Asias Street, Goudi 11527, Athens, Greece.
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MeSH Terms
Carcinoma, Hepatocellular / epidemiology*,  etiology
Case-Control Studies
Cholangiocarcinoma / epidemiology*,  etiology
Flavonoids / administration & dosage*
Greece / epidemiology
Hepacivirus / isolation & purification
Hepatitis B / epidemiology
Hepatitis B virus / isolation & purification
Hepatitis C / epidemiology
Liver Neoplasms / epidemiology*,  etiology
Middle Aged
Risk Factors
Reg. No./Substance:

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