Document Detail


Flavonoid-induced autophagy in hormone sensitive breast cancer cells.
MedLine Citation:
PMID:  19371773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activity of 8-prenylapigenin (8-PA) and its 3'-methoxylated analogue isocannflavin B (IsoB) was investigated in estrogen-dependent T47-D and estrogen-independent MDA-MB-231 human breast cancer cell lines. 8-PA showed a biphasic effect on T47-D cell proliferation, while no significant effect was observed on MDA-MB-231 cells. Conversely, IsoB exhibited only an inhibitory effect on T47-D cell proliferation, accompanied by the appearance of an intense intracytoplasmic vacuolization of autophagic origin. Moreover, biochemical analysis showed that IsoB reduced Akt phosphorylation and p21(Cip1) expression in T47-D cells. These data show that the prenylflavone moiety is a versatile platform for the induction and modulation of bioactivity.
Authors:
Elisa Brunelli; Giulia Pinton; Paolo Bellini; Alberto Minassi; Giovanni Appendino; Laura Moro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-14
Journal Detail:
Title:  Fitoterapia     Volume:  80     ISSN:  1873-6971     ISO Abbreviation:  Fitoterapia     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-11-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  16930290R     Medline TA:  Fitoterapia     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  327-32     Citation Subset:  IM    
Affiliation:
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and Drug and Food Biotechnology Center, Università degli Studi del Piemonte Orientale "Amedeo Avogadro", Via Bovio 6, 28100 Novara, Italy.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*,  therapeutic use
Autophagy / drug effects*
Breast Neoplasms / drug therapy*,  pathology
Cannabis
Cell Line, Tumor
Cell Proliferation / drug effects
Cyclin-Dependent Kinase Inhibitor p21 / metabolism
Cytoplasm / drug effects
Dose-Response Relationship, Drug
Estrogens / metabolism*
Female
Flavanones / pharmacology*
Flavones / pharmacology*
Flavonoids / pharmacology*,  therapeutic use
Humans
Humulus
Phosphorylation
Phytoestrogens / pharmacology,  therapeutic use
Phytotherapy*
Plant Extracts / pharmacology*,  therapeutic use
Prenylation
Proto-Oncogene Proteins c-akt / metabolism
Signal Transduction / drug effects
Vacuoles / drug effects
Chemical
Reg. No./Substance:
0/8-prenylnaringenin; 0/Antineoplastic Agents, Phytogenic; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Estrogens; 0/Flavanones; 0/Flavones; 0/Flavonoids; 0/Phytoestrogens; 0/Plant Extracts; 0/isocannflavin B; EC 2.7.11.1/Proto-Oncogene Proteins c-akt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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