Document Detail

Flavonoid classes and risk of peripheral arterial occlusive disease: a case-control study in Greece.
MedLine Citation:
PMID:  16234836     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the relation between specific flavonoid classes and peripheral arterial occlusive disease (PAOD), an important manifestation of atherosclerosis. DESIGN: Using data from a case-control study conducted in Greece in 1980 on the nutritional epidemiology of PAOD, we have exploited recently published databases on the content of foods in specific flavonoid classes to assess the relation between intake of these compounds and PAOD. SETTING: A major teaching hospital in Athens, Greece. SUBJECTS: Cases were 100 patients with PAOD and controls 100 patients with minor surgical conditions admitted to the same hospital. INTERVENTIONS: No interventions. All cases and controls were interviewed in the hospital wards, and a 110-food item semiquantitative food frequency questionnaire was administered by the same interviewer. RESULTS: Flavonols, flavones and perhaps flavan-3-ols were inversely associated with PAOD risk, the odds ratios (and 95% confidence intervals) for increments equal to the corresponding standard deviations being 0.41 (0.20-0.86), 0.56 (0.32-0.96) and 0.53 (0.26-1.05), respectively. Total flavonoids were also significantly inversely associated with PAOD. CONCLUSIONS: On the basis of these results, the biological properties of flavonoids and evidence concerning their relation to other manifestations of atherosclerosis, we conclude that dietary intake of specific classes of flavonoids, as well as total flavonoids, may have a protective effect against PAOD. SPONSORSHIP: This study was partially supported by a grant to Harvard University by the Samourkas Foundation.
P Lagiou; E Samoli; A Lagiou; Y Skalkidis; K Katsouyanni; E Petridou; D Trichopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  60     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-01     Completed Date:  2006-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  214-9     Citation Subset:  IM    
Department of Hygiene and Epidemiology, School of Medicine, University of Athens, Greece.
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MeSH Terms
Arterial Occlusive Diseases / epidemiology*,  etiology,  prevention & control
Case-Control Studies
Diet Surveys
Flavonoids / administration & dosage*,  classification*
Greece / epidemiology
Middle Aged
Odds Ratio
Risk Factors
Reg. No./Substance:
0/Flavonoids; 0/flavan-3-ol

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