Document Detail


Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin.
MedLine Citation:
PMID:  10913616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dioxins invade the body mainly through the diet, and produce toxicity through the transformation of aryl hydrocarbon receptor (AhR). An inhibitor of the transformation should therefore protect against the toxicity and ideally be part of the diet. We examined flavonoids ubiquitously expressed in plant foods as one of the best candidates, and found that the subclasses flavones and flavonols suppressed antagonistically the transformation of AhR induced by 1 nM of 2,3,7,8-tetrachlorodibenzo-p-dioxin, without exhibiting agonistic effects that transform AhR. The antagonistic IC(50) values ranged from 0.14 to 10 microM, close to the physiological levels in human.
Authors:
H Ashida; I Fukuda; T Yamashita; K Kanazawa
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  FEBS letters     Volume:  476     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-16     Completed Date:  2000-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Affiliation:
Laboratory of Food and Nutritional Chemistry, Faculty of Agriculture, Kobe University, Rokkodai, Nada-ku, 657-8501, Kobe, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
DNA Probes / genetics
Diet
Environmental Pollutants / antagonists & inhibitors,  toxicity*
Flavonoids / pharmacology*
Flavonols
Humans
Male
Rats
Rats, Sprague-Dawley
Receptors, Aryl Hydrocarbon / drug effects*,  genetics,  metabolism*
Tetrachlorodibenzodioxin / antagonists & inhibitors,  toxicity*
Chemical
Reg. No./Substance:
0/DNA Probes; 0/Environmental Pollutants; 0/Flavonoids; 0/Flavonols; 0/Receptors, Aryl Hydrocarbon; 1746-01-6/Tetrachlorodibenzodioxin

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