| Flavone is efficient to protect zebrafish fins from UV-induced damage. | |
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MedLine Citation:
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PMID: 22289409 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We used ultraviolet (UV)-induced fin damage in zebrafish as a system for evaluating the chemopreventive potential of flavonoids. Chemopreventive effects of each compound, including flavone, flavanone, and chalcone, on fin development were evaluated using Kaplan-Meier analysis and Cox proportional hazards regression. Results showed that 1) flavone has the highest capacity to protect zebrafish fins from UV-induced damages among other groups; 2) zebrafish fins in the UV+1 ppm flavone group are 1.02~9.60 times more likely to return to normal fins than ones in the UV-only group, but fins in the UV+20 ppm flavone group are only 0.45~5.66 times more likely to recover; and 3) flavone significantly reduced ROS production in UV-exposed zebrafish embryos, which may attenuate UV-mediated apoptosis. In conclusion, zebrafish can be used as a system for comparing the UV-protection efficacy of flavonoids. |
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Authors:
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I-Ting Tsai; Zhi-Shiang Yang; Zi-Yu Lin; Chi-Chung Wen; Chien-Chung Cheng; Yau-Hung Chen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Drug and chemical toxicology Volume: - ISSN: 1525-6014 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801723 Medline TA: Drug Chem Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, Tamkang University , Tamsui, New Taipei City , Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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