| Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines. | |
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MedLine Citation:
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PMID: 22213202 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Synovial sarcomas (SS) are soft tissue sarcomas with poor prognosis, displaying a lack of response to conventional cytotoxic chemotherapy. Although SS cell lines have moderate chemosensitivity to isofamide and doxorubicin therapy, the clinical prognosis is still poor. In this article, we showed that flavokawain B (FKB), a novel chalcone from kava extract, potently inhibits the growth of SS cell lines SYO-I and HS-SY-II through induction of apoptosis. Treatment with FKB increased caspase 8, 9, and 3/7 activity compared to vehicle-treated controls, indicating that both extrinsic and intrinsic apoptotic pathways were activated. Furthermore, FKB treatment of both cell lines resulted in increased mRNA and protein expression of death receptor-5 and the mitochondrial pro-apoptotic proteins Bim and Puma, while down-regulating the expression of an inhibitor of apoptosis, survivin in a dose-dependent manner. Our results suggest the natural compound FKB has a pro-apoptotic effect on SS cell lines. FKB may be a new chemotherapeutic strategy for patients with SS and deserves further investigation as a potential agent in the treatment of this malignancy. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res. |
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Authors:
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Toshinori Sakai; Ramez N Eskander; Yi Guo; Kap Jung Kim; Jason Mefford; Justin Hopkins; Nitin N Bhatia; Xiaolin Zi; Bang H Hoang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
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Title: Journal of orthopaedic research : official publication of the Orthopaedic Research Society Volume: - ISSN: 1554-527X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8404726 Medline TA: J Orthop Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Orthopaedic Research Society. |
Affiliation:
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Department of Orthopaedic Surgery, University of California Irvine, 101 The City Drive South, Orange, California 92868. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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