Document Detail

Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial.
MedLine Citation:
PMID:  23136121     Owner:  NLM     Status:  MEDLINE    
SCOPE: We examined whether flavan-3-ol-enriched dark chocolate, compared with standard dark and white chocolate, beneficially affects platelet function in healthy subjects, and whether this relates to flavan-3-ol bioavailability.
METHODS AND RESULTS: A total of 42 healthy subjects received an acute dose of flavan-3-ol-enriched dark, standard dark or white chocolate, in random order. Blood and urine samples were obtained just before and 2 and 6 h after consumption for measurements of platelet function, and bioavailability and excretion of flavan-3-ols. Flavan-3-ol-enriched dark chocolate significantly decreased adenosine diphosphate-induced platelet aggregation and P-selectin expression in men (all p ≤ 0.020), decreased thrombin receptor-activating peptide-induced platelet aggregation and increased thrombin receptor-activating peptide-induced fibrinogen binding in women (both p ≤ 0.041), and increased collagen/epinephrine-induced ex vivo bleeding time in men and women (p ≤ 0.042). White chocolate significantly decreased adenosine diphosphate-induced platelet P-selectin expression (p = 0.002) and increased collagen/epinephrine-induced ex vivo bleeding time (p = 0.042) in men only. Differences in efficacy by which flavan-3-ols affect platelet function were only partially explained by concentrations of flavan-3-ols and their metabolites in plasma or urine.
CONCLUSION: Flavan-3-ols in dark chocolate, but also compounds in white chocolate, can improve platelet function, dependent on gender, and may thus beneficially affect atherogenesis.
Luisa M Ostertag; Paul A Kroon; Sharon Wood; Graham W Horgan; Elena Cienfuegos-Jovellanos; Shikha Saha; Garry G Duthie; Baukje de Roos
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  57     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-23     Completed Date:  2013-07-11     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  191-202     Citation Subset:  IM    
Copyright Information:
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK.
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MeSH Terms
Adenosine Diphosphate / adverse effects,  metabolism
Biological Availability
Blood Platelets / drug effects*,  metabolism
Cacao / chemistry*
Fibrinogen / metabolism
Flavonoids / administration & dosage*
Middle Aged
P-Selectin / genetics,  metabolism
Platelet Aggregation / drug effects
Receptors, Thrombin / antagonists & inhibitors,  metabolism
Sex Factors
Young Adult
Grant Support
//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Flavonoids; 0/P-Selectin; 0/Receptors, Thrombin; 0/flavan-3-ol; 58-64-0/Adenosine Diphosphate; 9001-32-5/Fibrinogen
Comment In:
Mol Nutr Food Res. 2013 Oct;57(10):1693-4   [PMID:  24092633 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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