Document Detail

Flashback: psychiatric experimentation with LSD in historical perspective.
MedLine Citation:
PMID:  16086535     Owner:  NLM     Status:  MEDLINE    
In the popular mind, d-lysergic acid diethylamide (LSD) research in psychiatry has long been associated with the CIA-funded experiments conducted by Ewen Cameron at the Allen Memorial Institute in Montreal, Quebec. Despite this reputation, a host of medical researchers in the post World War II era explored LSD for its potential therapeutic value. Some of the most widespread trials in the Western world occurred in Saskatchewan, under the direction of psychiatrists Humphry Osmond (in Weyburn) and Abram Hoffer (in Saskatoon). These medical researchers were first drawn to LSD because of its ability to produce a "model psychosis." Their experiments with the drug that Osmond was to famously describe as a "psychedelic" led them to hypothesize and promote the biochemical nature of schizophrenia. This brief paper examines the early trials in Saskatchewan, drawing on hospital records, interviews with former research subjects, and the private papers of Hoffer and Osmond. It demonstrates that, far from being fringe medical research, these LSD trials represented a fruitful, and indeed encouraging, branch of psychiatric research occurring alongside more famous and successful trials of the first generation of psychopharmacological agents, such as chlropromazine and imipramine. Ultimately, these LSD experiments failed for 2 reasons, one scientific and the other cultural. First, in the 1950s and early 1960s, the scientific parameters of clinical trials shifted to necessitate randomized controlled trials, which the Saskatchewan researchers had failed to construct. Second, as LSD became increasingly associated with student riots, antiwar demonstrations, and the counterculture, governments intervened to criminalize the drug, restricting and then terminating formal medical research into its potential therapeutic effects.
Erika Dyck
Related Documents :
19444095 - Conduct of clinical trials in developing countries: a perspective.
2753525 - Methods of determining sample sizes in clinical trials.
15459625 - Executive summary of the national institute of neurological disorders and stroke confer...
12010405 - Conduct of clinical trials in developing countries.
19358225 - Quantitative signal detection using spontaneous adr reporting.
19594795 - From the brain to bad behaviour and back again: neurocognitive and psychobiological mec...
Publication Detail:
Type:  Historical Article; Journal Article; Review    
Journal Detail:
Title:  Canadian journal of psychiatry. Revue canadienne de psychiatrie     Volume:  50     ISSN:  0706-7437     ISO Abbreviation:  Can J Psychiatry     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-08-09     Completed Date:  2005-12-07     Revised Date:  2007-08-01    
Medline Journal Info:
Nlm Unique ID:  7904187     Medline TA:  Can J Psychiatry     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  381-8     Citation Subset:  IM    
Department of History, McMaster University, Hamilton, Ontario.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
History, 20th Century
History, 21st Century
Lysergic Acid Diethylamide / history*
Psychopharmacology / history*
Substance-Related Disorders / history*
Reg. No./Substance:
50-37-3/Lysergic Acid Diethylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Listening to the past: history, psychiatry, and anxiety.
Next Document:  Cost-utility of 2 maintenance treatments for older adults with depression who responded to a course ...