Document Detail

Flash pulmonary oedema: a rare but serious side effect of quinine sulphate.
MedLine Citation:
PMID:  22605805     Owner:  NLM     Status:  MEDLINE    
A 54-year-old woman with a background of psoriatic arthritis but no cardiac history was admitted with acute pulmonary oedema (November 2007) which required invasive ventilation and inotropic support. Investigations including ECG, transthoracic and transoesophageal echocardiography, coronary angiography, renal ultrasound and renal magnetic resonance angiography, cardiac MRI and urinary catecholamines were normal. Due to the lack of precipitant, the authors assumed this was due to nabumetone (a non-steroidal anti-inflammatory drug (NSAID)) which was stopped. A second similar episode (August 2008) was temporally associated with a depo steroid injection, although no NSAID was given. Steroids have subsequently been restricted. However, she was admitted again with pulmonary oedema (April 2010) despite not taking NSAIDs or steroids. At that stage, she advised us that she had been taking quinine sulphate on an as required basis and had taken oral doses before each episode of pulmonary oedema which the authors now believe to have been the precipitant.
Dan Raine; Alison Lee; Rachael Wiedmann
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-03-27
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-12     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Analgesics, Non-Narcotic / adverse effects*
Arthritis, Psoriatic / drug therapy
Diagnosis, Differential
Middle Aged
Pulmonary Edema / chemically induced*,  diagnosis,  therapy
Quinine / adverse effects*
Reg. No./Substance:
0/Analgesics, Non-Narcotic; A7V27PHC7A/Quinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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