Document Detail

Flare-up of pustular psoriasis with fluoxetine: possibility of a serotoninergic influence?
MedLine Citation:
PMID:  18850415     Owner:  NLM     Status:  MEDLINE    
In this article, we report two cases of pustular psoriasis flaring up after fluoxetine administration. A 21-year-old male patient with localized pustular psoriasis became erythrodermic following commencement of fluoxetine. Even though the lesions were unresponsive to cyclosporine A (Cyc A) treatment, dramatic resolution was observed with discontinuation of fluoxetine. A 44-year-old female patient with pustular psoriasis who was on Cyc A and acitretin therapy was given fluoxetine for her psychiatric symptoms. In the following 5 days, her lesions flared. Owing to previous experience, fluoxetine was stopped. Her lesions improved dramatically in the following 3 days. Exacerbation of psoriasis with antidepressant therapy has been rarely described. An extensive review of the literature revealed four such cases, all of which were seen after the use of selective serotonin reuptake inhibitors (SSRI). A serotoninergic influence in the etiopathogenesis of psoriasis may be possible together with a pharmacogenetic difference in the drug metabolism of these patients. Considering the two patients we presented and the patients previously reported in the literature, aggravation of pustular psoriasis by SSRI should be borne in mind.
Emine Tamer; Gunes Gur; Muhterem Polat; Nuran Alli
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  20     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-26     Completed Date:  2009-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
1st Dermatology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey.
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MeSH Terms
Depressive Disorder / diagnosis,  drug therapy
Dermatitis, Exfoliative / chemically induced*,  physiopathology
Drug Eruptions / etiology,  physiopathology
Fluoxetine / adverse effects*,  therapeutic use
Follow-Up Studies
Psoriasis / drug therapy*,  pathology,  psychology
Risk Assessment
Serotonin Uptake Inhibitors / adverse effects*,  therapeutic use
Severity of Illness Index
Withholding Treatment
Young Adult
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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