| Flagellum assembly and function during the Leishmania life cycle. | |
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MedLine Citation:
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PMID: 20541962 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During a complex digenetic life cycle flagellated Leishmania parasites alternate between promastigote and amastigote forms which differ significantly in cellular morphology and flagellum length. Recent studies have provided important new insights into mechanisms by which Leishmania regulate expression of genes required for flagellum assembly, and mechanisms used to modify flagellum length. While the critical role of the promastigote flagellum in parasite biology has long been appreciated, the importance of the amastigote flagellum has often been disregarded. However, recent work suggests that the 'rudimentary' amastigote flagellum may serve indispensable roles in cellular organisation, and/or sensory perception, which are critical for intracellular survival of Leishmania within host macrophages. |
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Authors:
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Eva Gluenz; Michael L Ginger; Paul G McKean |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-11 |
Journal Detail:
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Title: Current opinion in microbiology Volume: 13 ISSN: 1879-0364 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 473-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Flagella / genetics, physiology* Gene Expression Regulation Host-Parasite Interactions Immune Evasion Leishmania / genetics, growth & development*, immunology Life Cycle Stages Macrophages / parasitology |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council; //Wellcome Trust |
| Comments/Corrections | |
Comment In:
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Curr Opin Microbiol. 2010 Aug;13(4):450-2
[PMID:
20579933
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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