| Flagellar and ciliary beating: the proven and the possible. | |
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MedLine Citation:
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PMID: 20145000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The working mechanism of the eukaryotic flagellar axoneme remains one of nature's most enduring puzzles. The basic mechanical operation of the axoneme is now a story that is fairly complete; however, the mechanism for coordinating the action of the dynein motor proteins to produce beating is still controversial. Although a full grasp of the dynein switching mechanism remains elusive, recent experimental reports provide new insights that might finally disclose the secrets of the beating mechanism: the special role of the inner dynein arms, especially dynein I1 and the dynein regulatory complex, the importance of the dynein microtubule-binding affinity at the stalk, and the role of bending in the selection of the active dynein group have all been implicated by major new evidence. This Commentary considers this new evidence in the context of various hypotheses of how axonemal dynein coordination might work. |
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Authors:
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Charles B Lindemann; Kathleen A Lesich |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Journal of cell science Volume: 123 ISSN: 1477-9137 ISO Abbreviation: J. Cell. Sci. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: England |
Other Details:
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Languages: eng Pagination: 519-28 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA. lindeman@oakland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axoneme / physiology, ultrastructure Cilia / physiology*, ultrastructure Dyneins / physiology Flagella / physiology*, ultrastructure Humans Models, Biological Molecular Motor Proteins / physiology Movement / physiology |
| Chemical | |
Reg. No./Substance:
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0/Molecular Motor Proteins; EC 3.6.4.2/Dyneins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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