Document Detail


Fixed-dose combinations for emerging treatment of pain.
MedLine Citation:
PMID:  22420908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Pain is a large and growing medical need that is not currently being fully met, primarily due to the shortcomings of existing analgesics (insufficient efficacy or limiting side-effects). Better outcomes might be achieved using a combination of analgesics. The ratio of the combinations matters and should therefore be evaluated using rigorous quantitative and well-documented analysis.
AREAS COVERED: Advances have been made in understanding the normal physiology of pain processing, including the pathways and neurotransmitters involved. Insight has also been gained about physiological processes that can lead to different 'types' of pain and the transition from acute to chronic pain conditions. This 'multimechanistic' nature of most pains is better matched using a 'multimechanistic' rather than 'monomechanistic' analgesic approach. Such an approach - and the experimental design and data analysis to assess optimal combinations - is described and discussed.
EXPERT OPINION: There are sound pharmacologic, as well as practical, reasons for using combinations of drugs to treat pain. Compared with single agents, they offer a potential better match to the underlying pain physiology and thus greater efficacy or reduced side effects. The optimal efficacy and side-effect ratio must be determined in a scientifically rigorous manner.
Authors:
Robert B Raffa; Ronald J Tallarida; Robert Taylor; Joseph V Pergolizzi
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-03-16
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  13     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-09-14     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  1261-70     Citation Subset:  IM    
Affiliation:
Temple University School of Pharmacy, Department of Pharmaceutical Sciences, 3307 N. Broad Street, PA 19140, USA. robert.raffa@temple.edu
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MeSH Terms
Descriptor/Qualifier:
Analgesics / administration & dosage*,  adverse effects
Animals
Drug Combinations
Drug Evaluation, Preclinical
Drug Therapy, Combination
Humans
Pain / diagnosis,  drug therapy*,  etiology
Pain Management / methods*
Risk Assessment
Treatment Outcome
Chemical
Reg. No./Substance:
0/Analgesics; 0/Drug Combinations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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