Document Detail

Fixed dose combination of lamivudine, stavudine and nevirapine in the treatment of pediatric HIV infection: a preliminary report.
MedLine Citation:
PMID:  17684304     Owner:  NLM     Status:  MEDLINE    
To assess efficacy and safety of fixed-dose combination (FDC) of lamivudine, stavudine and nevirapine in the treatment of pediatric HIV- infection, it was administered in the form of oral suspension (Group-A) or dispersible tablet (Group-B). Assessment of improvement in symptoms, CD4 count and adverse drug reactions was done every three months. Baseline CD4 count/mm3 in Group-A (n = 13) patients aged < or =1 yr, 1 to 5 yr and > or = 6 yr increased by 79, 152, 342, 988; 422.8, 514.2, 711.6, 832.6; and 205, 332.7, 516.8, 761.6 after 3, 6, 9 and 12 months of therapy, respectively. The corresponding baseline CD4 count/mm3 in Group-B (n = 8) patients in the three age categories increased by 370, 644.5 and 314 after 3 months, respectively. Improvement in the clinical category was observed in all the patients taking study medication, including weight gain; and decreased incidence of fever, diarrhea, infections and hospitalization. None of the patients had any drug-related adverse effect. Adherence to the regimen was < 95 % and there were no treatment failures.
Tripati Pensi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  44     ISSN:  0019-6061     ISO Abbreviation:  Indian Pediatr     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-08-08     Completed Date:  2007-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  519-21     Citation Subset:  IM    
Department of Pediatrics, R.M.L. Hospital, New Delhi, India.
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MeSH Terms
Anti-HIV Agents / therapeutic use*
CD4 Lymphocyte Count
Child, Preschool
Drug Combinations
Follow-Up Studies
HIV Infections / drug therapy*,  immunology,  virology
Lamivudine / administration & dosage,  therapeutic use*
Nevirapine / administration & dosage,  therapeutic use*
Prospective Studies
Stavudine / administration & dosage,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Anti-HIV Agents; 0/Drug Combinations; 129618-40-2/Nevirapine; 134678-17-4/Lamivudine; 3056-17-5/Stavudine

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