Document Detail

Fixed-combination products in the management of acne vulgaris.
MedLine Citation:
PMID:  20408517     Owner:  NLM     Status:  MEDLINE    
Acne vulgaris is the most common dermatologic disorder in the United States. Although its cause is unknown, various factors are implicated in its pathogenesis. No single topical antiacne medication acts on all the major pathophysiologic events. Combined use of agents with different modes of action provides better patient outcomes than monotherapy. Topical fixed-combination therapies include antibiotics with benzoyl peroxide (BPO) or retinoids, and retinoids with BPO. With increased efficacy can come increased irritation from the combination or formulation excipients. Surfactants, preservatives, and high levels of organic solvents including alcohols found in some products are potential irritants. This review considers data on topical fixed-combination acne medications and developments focused on newer lower concentration, optimized formulations aimed at reducing dryness and irritation without compromising efficacy. In the absence of direct comparative clinical trials, this review provides timely guidance for clinicians on the use of these agents.
Linda Stein Gold
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cutis     Volume:  85     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-05-18     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-7     Citation Subset:  IM    
Henry Ford Hospital, Detroit, Michigan, USA.
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MeSH Terms
Acne Vulgaris / drug therapy*,  etiology,  pathology
Anti-Bacterial Agents / administration & dosage*
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
Benzoyl Peroxide / administration & dosage*
Dermatologic Agents / administration & dosage*
Drug Combinations
Retinoids / administration & dosage*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Dermatologic Agents; 0/Drug Combinations; 0/Retinoids; 94-36-0/Benzoyl Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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