Document Detail

Five years' experience of preimplantation genetic diagnosis in the Parisian Center: outcome of the first 441 started cycles.
MedLine Citation:
PMID:  17074325     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the evolution of techniques and strategies and to evaluate the results of preimplantation genetic diagnosis (PGD) from January 2000 to December 2004 in chromosomal, monogenic and mitochondrial DNA disorders treated at our institution. DESIGN: Retrospective study. SETTING: Single French Parisian PGD center. PATIENT(S): Patients at risk of transmitting a serious genetic disorder to their offspring. INTERVENTION(S): 171 couples enrolled in the program undergoing stimulated and frozen embryo replacement cycles with PGD. MAIN OUTCOME MEASURE(S): Results of the 441 first PGD cycles performed for various genetic conditions. RESULT(S): During 5 years, 416 stimulation and 25 frozen embryo replacement cycles were started, among which 52 clinical and 47 ongoing pregnancies occurred. In stimulation cycles, the overall ongoing pregnancy rate was 24% per embryo transfer, 11% per started cycle, and 27% per couple. The implantation rate was 16%. CONCLUSION(S): These encouraging results demonstrate that PGD might be considered as a valid alternative to prenatal diagnosis. Nevertheless, couples referred for PGD must be selected and counseled appropriately, considering the complexity of the treatment and the relatively low take-home baby rate.
Estelle Feyereisen; Julie Steffann; Serge Romana; Marc Lelorc'h; Pierre Ray; Violaine Kerbrat; Gérard Tachdjian; René Frydman; Nelly Frydman
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Publication Detail:
Type:  Journal Article     Date:  2006-10-30
Journal Detail:
Title:  Fertility and sterility     Volume:  87     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-01     Completed Date:  2007-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  60-73     Citation Subset:  IM    
Service de Gynécologie-Obstétrique et de Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart, France.
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MeSH Terms
France / epidemiology
Genetic Diseases, X-Linked / diagnosis*,  epidemiology*,  genetics,  prevention & control
Genetic Predisposition to Disease / epidemiology*,  genetics
Longitudinal Studies
Middle Aged
Outcome Assessment (Health Care) / methods*,  statistics & numerical data
Pregnancy Outcome / epidemiology*
Preimplantation Diagnosis / statistics & numerical data*
Reproducibility of Results
Retrospective Studies
Risk Assessment / methods*
Risk Factors
Sensitivity and Specificity
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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