| Five year time course of celiac disease serology during gluten free diet: results of a community based "CD-Watch" program. | |
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MedLine Citation:
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PMID: 20598661 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Little information is available on the effect of a follow-up strategy in celiac disease patients during gluten-free diet. AIMS: To assess 5 year time course of t-transglutaminase antibodies (t-TG) in celiac disease patients enrolled in a community based follow-up program. METHODS: Annual t-TG testing and periodical clinic visit in 2245 patients. RESULTS: Proportion of patients with negative t-TG progressively increased from 83% to 93% during the 5-year follow-up: poor adherence to gluten-free diet (HR 4.764), long duration of gluten-free diet (HR 0.929) and female gender (HR 1.472) were independently associated with serological outcome. In individual patients, 69% tested t-TG "persistently negative", 1% "persistently positive" and 30% "intermittently negative or positive". By applying mathematical modelling to t-TG conversion rates observed in this latter group at beginning and end of the follow-up program, the predicted proportion of t-TG negative population increased from 90% to 95% over 5 years. CONCLUSIONS: Time-course of t-TG serology in the community fluctuates in 1/3 of celiac disease patients suggesting inconstant adherence to gluten-free diet and need of follow-up strategy. Periodical serological and clinical follow-up is a viable and efficacious strategy to promote adherence to gluten-free diet as inferred from time-course of t-TG serology. |
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Authors:
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Barbara Zanini; Francesco Lanzarotto; Alessandra Mora; Stefania Bertolazzi; Daniele Turini; Bruno Cesana; Francesco Donato; Chiara Ricci; Fulvio Lonati; Francesco Vassallo; Carmelo Scarcella; Alberto Lanzini |
Publication Detail:
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Type: Journal Article Date: 2010-07-02 |
Journal Detail:
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Title: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Volume: 42 ISSN: 1878-3562 ISO Abbreviation: Dig Liver Dis Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100958385 Medline TA: Dig Liver Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 865-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2010. Published by Elsevier Ltd. |
Affiliation:
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Gastroenterology Unit, University and Spedali Civili of Brescia, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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