Document Detail

Five year study of cardiovascular risk factors in Japanese people: implications concerning new onset of metabolic syndrome.
MedLine Citation:
PMID:  20045994     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The incidence of metabolic syndrome (MetS) has not been fully studied. METHODS AND RESULTS: The data of 35,534 subjects who underwent a health examination both in 1996 and 2001 were analyzed. Since the waist circumference was not available, modified criteria of MetS was used for those with 3 or more of the following items: 1) body mass index (BMI) >or=25 kg/m(2), 2) blood pressure >or=130 mm Hg in systolic and/or >or=85 mm Hg in diastolic, 3) triglycerides >or=150 mg/dL, 4) high-density lipoprotein (HDL) cholesterol <or=40 mg/dL in men, <or=50 mg/dL in women, and 5) fasting blood glucose (FBG) >or=100 mg/dL. The subjects who underwent therapy for hypertension, diabetes mellitus, and high TG were considered to have these items. The incidence of MetS over 5 years was determined and its risks were evaluated by Cox proportional-hazards models. During the follow-up of exactly 5 years, MetS developed in 2,853 (9.32%) among 30,623 subjects who had no MetS at baseline. The subjects who developed MetS were older, and had elevated BMI, blood pressure, TG and FBG (p<0.001 for all) and lower HDL (p<0.034 for men and p<0.001 for women). Each item of MetS and their combination was associated with a higher risk to develop MetS. Obesity (BMI >or=25 kg/m(2)) alone or in combination with another item was associated with a higher risk to develop MetS suggesting it plays a key role. CONCLUSION: MetS using BMI developed in 9.32% over 5 years or 1.86%/year. Each item of MetS or their combination showed a high risk to develop MetS. Obesity was associated with a higher hazard ratio to develop MetS.
Akiko Suzuki; Keiichiro Kosuge; Osamu Nanyu; Hiroshi Watanabe; Toru Watanabe; Yoshimaru Usuda; Shigeru Sasaki; Yoshifusa Aizawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  49     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-04     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Division of Endocrinology and Metabolism, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
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MeSH Terms
Aged, 80 and over
Body Mass Index
Cardiovascular Diseases / etiology*
Cohort Studies
Hyperlipidemias / complications
Hypertension / complications
Japan / epidemiology
Metabolic Syndrome X / complications*,  diagnosis,  epidemiology*
Middle Aged
Obesity / complications
Risk Factors
Young Adult

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