| Five-year results of a prospective, randomized, controlled study evaluating treatment of intra-bony defects with a natural bone mineral and GTR. | |
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MedLine Citation:
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PMID: 17243997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Treatment with a natural bone mineral (NBM) and a guided tissue regeneration (GTR) has been shown to promote periodontal regeneration. However, until now there are only very limited data on the long-term clinical results following this regenerative technique. AIM: To present the 5-year results of a prospective, randomized, controlled clinical study evaluating the treatment of deep intra-bony defects either with open flap debridement (OFD) and a combination of an NBM and GTR (test) or OFD alone (control). METHODS: Nineteen patients diagnosed with advanced chronic periodontitis, and each of whom displayed one intra-bony defect, received randomly the test or the control treatment. Results were evaluated at baseline, at 1 and at 5 years following therapy. RESULTS: No statistically significant differences in any of the investigated parameters were observed at baseline between the two groups. At 1 year after therapy, the test group showed a reduction in mean probing depth (PD) from 9.1+/-1.1 to 3.7+/-0.8 mm (p<0.001) and a change in mean clinical attachment level (CAL) from 10.4+/-1.3 to 6.4+/-1.2 mm (p<0.001). At 5 years, mean PD and CAL measured 4.3+/-0.8 and 6.7+/-1.6 mm, respectively. At 5 years, both PD and CAL were statistically significantly improved compared with baseline (p<0.001) without statistically significant differences between the 1- and 5-year results. In the control group, mean PD was reduced from 8.9+/-1.3 to 4.9+/-1.2 mm (p<0.001) and mean CAL changed from 10.6+/-1.4 to 8.8+/-1.5 mm (p<0.01). At 5 years, mean PD and CAL measured 5.6+/-1.1 and 9.1+/-1.3 mm, respectively, and were still statistically significantly improved compared with baseline (p<0.01). No statistically significant differences were found between the 1- and 5-year results. The test treatment, at both 1 and 5 years, yielded statistically significantly higher CAL gains than the control one (p<0.01). Compared with baseline, at 5 years a CAL gain of > or =3 mm was found in nine defects (90%) of the test group but in none of the defects treated with OFD alone. CONCLUSIONS: It was concluded that (i) treatment of intra-bony defects with OFD+NBM+GTR may result in significantly higher CAL gains than treatment with OFD, and (ii) the clinical results obtained after both treatments can be maintained over a period of 5 years. |
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Authors:
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Anton Sculean; Frank Schwarz; Giovanni C Chiantella; Nikolaos Donos; Nicole B Arweiler; Michel Brecx; Jürgen Becker |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical periodontology Volume: 34 ISSN: 0303-6979 ISO Abbreviation: J. Clin. Periodontol. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-24 Completed Date: 2007-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: Denmark |
Other Details:
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Languages: eng Pagination: 72-7 Citation Subset: D; IM |
Affiliation:
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Department of Periodontology, Radboud University Medical Center, Nijmegen, The Netherlands. a.sculean@dent.umcn.nl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Alveolar Bone Loss
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classification,
surgery* Biocompatible Materials / therapeutic use Bone Matrix / transplantation* Bone Substitutes / therapeutic use* Collagen / therapeutic use Female Follow-Up Studies Gingival Recession / classification, surgery Guided Tissue Regeneration, Periodontal / methods* Humans Male Membranes, Artificial Middle Aged Minerals / therapeutic use* Periodontal Attachment Loss / classification, surgery Periodontal Pocket / classification, surgery Periodontitis / surgery Prospective Studies Surgical Flaps Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Bio-Gide; 0/Bio-Oss; 0/Biocompatible Materials; 0/Bone Substitutes; 0/Membranes, Artificial; 0/Minerals; 9007-34-5/Collagen |
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