| Five-year follow-up with low-dose tacrolimus in patients with myasthenia gravis. | |
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MedLine Citation:
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PMID: 21035148 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junction, and prednisolone (PSL) and immunosuppressive drugs are available for treatment. Tacrolimus, a macrolide that suppresses the immune system, is used as a second-line treatment for MG. There have been several reports of the effects of tacrolimus over a few years of follow-up. Here, we report data from 9 patients with steroid-dependent generalized MG treated with low-dose tacrolimus (2-3 mg/day) for 5 years. Following treatment with tacrolimus, mean MG-activities of daily living score improved from 4.6 at baseline to 3.3 at 5 years after initiation of treatment. Mean dose of PSL could also be reduced, from 24.0 mg/day at baseline to 10.2 mg/day at 5 years, although there were no cases of total withdrawal of PSL. By contrast, 5 of the 9 patients experienced exacerbation of symptoms and transient increases in PSL dose during the 5-year period. Tacrolimus is an important option for treatment of MG; however, careful management is needed for long-term treatment with this drug. |
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Authors:
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Naoya Minami; Naoto Fujiki; Shizuki Doi; Koji Shima; Masaaki Niino; Seiji Kikuchi; Hidenao Sasaki |
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Publication Detail:
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Type: Journal Article Date: 2010-10-29 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 300 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 59-62 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurology, Hokkaido Medical Center, Sapporo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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