Document Detail

Five-year follow up of selective laser trabeculoplasty in Chinese eyes.
MedLine Citation:
PMID:  15281969     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study the effectiveness and safety of selective laser trabeculoplasty (SLT) on primary open-angle glaucoma and ocular hypertension in Chinese eyes. METHODS: This was a prospective randomized controlled clinical study in which 58 eyes of 29 patients with primary open-angle glaucoma or ocular hypertension were included. One eye of each patient was randomized to receive SLT (Group 1) and the fellow eyes received medical treatment (Group 2). Patients were evaluated after laser treatment at 2 h, 1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months, and then yearly. RESULTS: All patients (13 male, 16 female) were Chinese. The mean age was 51.9 +/- 14.7 years. The mean baseline intraocular pressure was 26.8 +/- 5.6 mmHg in group 1 and 26.2 +/- 4.2 mmHg in group 2 (P = 0.62). The failure rate, defined as intraocular pressure >21 mmHg with maximal medications, was 17.2% in group 1 and 27.6% in group 2 at 5-year follow-up (P = 0.53). Eight eyes (27.6%) in group 1 required medications to control the intraocular pressure to below 21 mmHg. There was no statistically significant difference in the intraocular pressure reductions between the two groups at all time intervals (P > 0.05). The mean number of antiglaucoma medications was significantly lower in the SLT than the medical treatment group up to 5 years of follow up (P < 0.001). Transient post-SLT intraocular pressure spike >5 mmHg was observed in three eyes (10.3%). CONCLUSION: With fewer medications, SLT gives similar intraocular pressure reduction to medical therapy alone in Chinese patients with primary open-angle glaucoma or ocular hypertension.
Jimmy S M Lai; John K H Chua; Clement C Y Tham; Dennis S C Lam
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  32     ISSN:  1442-6404     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-29     Completed Date:  2004-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  368-72     Citation Subset:  IM    
Department of Ophthalmology, United Christian Hospital, Kwun Tong, Kowloon, Hong Kong, China.
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MeSH Terms
Asian Continental Ancestry Group / ethnology
Follow-Up Studies
Glaucoma, Open-Angle / ethnology,  surgery*
Hong Kong / epidemiology
Intraocular Pressure
Laser Therapy*
Middle Aged
Ocular Hypertension / ethnology,  surgery
Prospective Studies
Tonometry, Ocular
Trabecular Meshwork / surgery*
Trabeculectomy / methods*
Comment In:
Clin Experiment Ophthalmol. 2004 Aug;32(4):347-8   [PMID:  15281964 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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