Document Detail

Five-year follow-up of high-risk infants with family history of allergy who were exclusively breast-fed or fed partial whey hydrolysate, soy, and conventional cow's milk formulas.
MedLine Citation:
PMID:  9144119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Allergy is a common cause of illness. The effect of feeding different infant formulas on the incidence of atopic disease and food allergy was assessed in a prospective randomized double-blind study of high-risk infants with a family history of atopy. METHODS: 216 high-risk infants whose mothers had elected not to breast-feed were randomized to receive exclusively a partial whey hydrolysate formula or a conventional cow's milk formula or a soy formula until 6 months of age. Seventy-two high risk infants breast-fed for > or = 4 months were also studied. RESULTS: Follow-up until 5 years of age showed a significant lowering in the cumulative incidence of atopic disease in the breast-fed (odds ratio 0.422 [0.200-0.891]) and the whey hydrolysate (odds ratio 0.322 [0.159-0.653) groups, compared with the conventional cow's milk group. Soy formula was not effective (odds ratio 0.759 [0.384-1.501]). The occurrence of both eczema and asthma was lowest in the breast-fed and whey hydrolysate groups and was comparable in the cow's milk and soy groups. Similar significant differences were noted in the 18-60 month period prevalence of eczema and asthma. Eczema was less severe in the whey hydrolysate group compared with the other groups. Double-blind placebo-controlled food challenges showed a lower prevalence of food allergy in the whey hydrolysate group compared with the other formula groups. CONCLUSIONS: Exclusive breast-feeding or feeding with a partial whey hydrolysate formula is associated with lower incidence of atopic disease and food allergy. This is a cost-effective approach to the prevention of allergic disease in children.
R K Chandra
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  24     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-14     Completed Date:  1997-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  380-8     Citation Subset:  IM    
Department of Pediatrics, Memorial University of Newfoundland, Canada.
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MeSH Terms
Asthma / prevention & control
Breast Feeding*
Double-Blind Method
Eczema / prevention & control
Follow-Up Studies
Food Hypersensitivity / prevention & control
Hypersensitivity / epidemiology,  prevention & control*
Infant Food*
Infant, Newborn
Milk Proteins
Prospective Studies
Risk Factors
Reg. No./Substance:
0/Milk Proteins; 0/Placebos; 0/whey protein
Comment In:
J Pediatr Gastroenterol Nutr. 1997 Apr;24(4):442-6   [PMID:  9144130 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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