| Five-year follow-up on the effect of oral acyclovir after penetrating keratoplasty for herpetic keratitis. | |
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MedLine Citation:
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PMID: 19654536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the long-term effect of oral acyclovir administered during the first 6 months after penetrating keratoplasty (PK) for herpetic eye disease (HED). METHODS: A 5-year follow-up was undertaken for a patient population from a placebo-controlled, randomized trial on acyclovir prophylaxis after keratoplasty. In this former study the effectiveness of oral acyclovir prophylaxis was significant during the first 2 years after keratoplasty. Prospective data such as graft survival, graft clarity, vascularization, infective events, and rejection episodes were obtained from the national keratoplasty follow-up registry. Additional clinical data were derived from the medical charts. RESULTS: For 47 of the original 63 enrolled patients, the 5-year follow-up was completed. Comparing the acyclovir group with the placebo group, we found that with regard to the cumulative clinically evident recurrences, there was a statistically significant lower monthly event rate in the acyclovir group (P = 0.037). There were no statistically significant differences in visual acuity or in the use of oral aciclovir between the two treatment groups. The incidences of graft failure, vascularization, and medication or surgery for glaucoma were too low to analyze differences between the two groups. CONCLUSION: The results of our study suggest that oral acyclovir prescribed during the first 6 months after PK for HED protects against clinically evident HED recurrences during the first 5 years following PK. |
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Authors:
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Aateke F G Jansen; Wilhelmina J Rijneveld; Lies Remeijer; Henny J M Völker-Dieben; Catharina A Eggink; Annette J M Geerards; Paul G H Mulder; Jeroen van Rooij |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Cornea Volume: 28 ISSN: 1536-4798 ISO Abbreviation: Cornea Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8216186 Medline TA: Cornea Country: United States |
Other Details:
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Languages: eng Pagination: 843-5 Citation Subset: IM |
Affiliation:
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Rotterdam Eye Hospital, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyclovir
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administration & dosage* Administration, Oral Antiviral Agents / administration & dosage* Drug Administration Schedule Follow-Up Studies Graft Rejection Graft Survival Humans Kaplan-Meiers Estimate Keratitis, Herpetic / drug therapy*, surgery* Keratoplasty, Penetrating* Postoperative Care* Postoperative Complications Postoperative Period Recurrence / prevention & control Treatment Outcome Visual Acuity |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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