Document Detail


Five putative drug resistance parameters (MDR1/P-glycoprotein, MDR-associated protein, glutathione-S-transferase, bcl-2 and topoisomerase IIalpha) in 57 newly diagnosed acute myeloid leukaemias. Swiss Group for Clinical Cancer Research (SAKK).
MedLine Citation:
PMID:  9338618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RESULTS: MDR1- and MRP mRNA levels correlated with each other (r=0.54, Spearman), FABM4/M5 and extramedullary disease. "Low" bcl-2-mRNA predicted longer PFS: 22 months vs. 7 months (median,p=0.02, log rank), and longer OS: 64 months vs. 14 months (p=0.06). "Low" topo IIalpha predicted poorer outcome: median PFS 9 vs. 19 months (p=0.03); median survival 12 months vs. "not reached" (p=0.03). An improved outcome tendency, albeit nonsignificant, was seen in p-gp-negative patients. In a Cox model adjusted for age, performance status, presence of Auer rods, FAB type and clinical response, bcl-2 and topo IIalpha mRNA levels retained their predictive values.
Authors:
A Lohri; B van Hille; M Bacchi; M Fopp; F Joncourt; J Reuter; T Cerny; M F Fey; R Herrmann
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of haematology     Volume:  59     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-03     Completed Date:  1997-11-03     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  206-15     Citation Subset:  IM    
Affiliation:
Department of Research, University Clinic, Basel, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Antigens, Neoplasm
DNA Topoisomerases, Type II* / genetics*
DNA-Binding Proteins
Drug Resistance, Multiple / genetics
Drug Resistance, Neoplasm / genetics*
Genes, MDR
Glutathione Transferase / genetics*
Humans
Isoenzymes / genetics*
Leukemia, Myeloid / drug therapy,  genetics*,  physiopathology
Middle Aged
Neoplasm Proteins / genetics
P-Glycoprotein / genetics*
Predictive Value of Tests
Prognosis
Proto-Oncogene Proteins c-bcl-2 / genetics*
Tumor Markers, Biological*
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/DNA-Binding Proteins; 0/Isoenzymes; 0/Neoplasm Proteins; 0/P-Glycoprotein; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tumor Markers, Biological; EC 2.5.1.18/Glutathione Transferase; EC 5.99.1.3/DNA Topoisomerases, Type II; EC 5.99.1.3/DNA topoisomerase II alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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