| Five patients with iodine-induced hyperthyroidism. | |
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MedLine Citation:
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PMID: 6235747 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iodine-induced hyperthyroidism has been frequently described when iodine is introduced into an iodine-deficient area. However, it may also occur in patients with and without previous thyroid disease residing in iodine-sufficient areas. Five patients with iodine-induced hyperthyroidism seen in a 12-month period are described. All were exposed to iodine in the form of commonly used drugs (Betadine, Iodo-Niacin, amiodarone, and radiographic contrast dyes). The cause of iodine-induced hyperthyroidism is unclear, but it is probably more common in patients with goiters containing previously existing areas of autonomous function or iodine-poor thyroglobulin. Iodine-induced hyperthyroidism usually abates after iodine withdrawal in patients with multinodular goiters or normal thyroid glands. The hyperthyroidism is usually treated with beta-blockers and antithyroid thionamide drugs, although reinstitution of iodine to block thyroid hormone release or corticosteroids occasionally may be necessary. Iodine-containing drugs should be given with caution to patients with underlying thyroid disease. |
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Authors:
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R Rajatanavin; M Safran; W A Stoller; J P Mordes; L E Braverman |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of medicine Volume: 77 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-09-07 Completed Date: 1984-09-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 378-84 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amiodarone / adverse effects Chlorobutanol / adverse effects Coloring Agents / adverse effects Coronary Artery Bypass Drug Combinations / adverse effects Female Goiter, Nodular / drug therapy Graves Disease / drug therapy Humans Hyperthyroidism / chemically induced*, drug therapy, physiopathology Iodine / adverse effects* Iodine Radioisotopes / therapeutic use Male Middle Aged Niacinamide / adverse effects Postoperative Complications Povidone-Iodine / adverse effects Propylthiouracil / therapeutic use Radiographic Image Enhancement / adverse effects Sodium Iodide / adverse effects Thyroid Hormones / analysis |
| Grant Support | |
ID/Acronym/Agency:
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AM-07302/AM/NIADDK NIH HHS; AM-19819/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Drug Combinations; 0/Iodine Radioisotopes; 0/Thyroid Hormones; 0/iodo-niacin; 1951-25-3/Amiodarone; 25655-41-8/Povidone-Iodine; 51-52-5/Propylthiouracil; 57-15-8/Chlorobutanol; 7553-56-2/Iodine; 7681-82-5/Sodium Iodide; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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