Document Detail


Five new microsatellite polymorphisms at the q21 region of human chromosome 21.
MedLine Citation:
PMID:  7814016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five clones, containing polymorphic CA-repeat sequences, have been isolated from a specific human chromosome 21 phage library and have been localised to band q21 of chromosome 21 using a somatic cell hybrid panel. These highly repetitive sequences (D21S1263, D21S1264, D21S1415, D21S1417 and D21S1420) have been characterised in the CEPH reference parents and have heterozygosities ranging from 0.30 to 0.81 and an average polymorphism information content (PIC) of 0.62. The relative order of these markers, based on the somatic cell hybrid panel, is cen-D21S1417, D21S1420-D21S1263, D21S1415-D21S1264-tel. The most polymorphic marker (D21S1264) has been included in the chromosome 21 genetic map. They have also been localised in the CEPH/Généthon YAC panel, providing a refined localisation of these polymorphic sequences. These five CA-repeat markers should provide a better characterisation of the q21 region of chromosome 21.
Authors:
A Bosch; S Wiemann; J Guimerà; W Ansorge; D Patterson; X Estivill
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human genetics     Volume:  95     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-02-03     Completed Date:  1995-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Affiliation:
Molecular Genetics Department, Hospital Duran i Reynals, Barcelona, Catalunya, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Chromosome Mapping
Chromosomes, Artificial, Yeast
Chromosomes, Human, Pair 21*
Cricetinae
Cricetulus
DNA Primers
DNA, Satellite*
Genetic Markers
Humans
Hybrid Cells
Molecular Sequence Data
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
HD17449/HD/NICHD NIH HHS; HG00716/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA, Satellite; 0/Genetic Markers

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