Five hundred years of the nephrotic syndrome: 1484-1984.

Five hundred years of the nephrotic syndrome: 1484-1984.

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MedLine Citation:	PMID: 3909583 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	The nephrotic syndrome has emerged over several centuries as the consequence of continued profuse proteinuria, arising in turn from a variety of lesions affecting the glomerulus which impair glomerular ability to retain plasma proteins, in particular, albumin. As a syndrome, it has its own complications and requires its own management irrespective of the underlying lesions. Dissection of these by renal biopsy and by clinical investigation reveals a variety of systemic diseases which affect the kidney, but a majority of primary immune-based diseases appear unique to the glomerulus. Whether the lesion called by Müller and Munk 'nephrosis', and now called minimal change disease and focal segmental glomerulosclerosis is one disease or many, is the subject of intense debate at the moment, as is the relationship between two types of lesion. Only a better understanding of their pathogenesis, and of how the glomerulus normally retains plasma protein, will solve this knotty problem.

Authors:	J S Cameron
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Publication Detail:	Type: Historical Article; Journal Article; Review
Journal Detail:	Title: The Ulster medical journal Volume: 54 Suppl ISSN: 0041-6193 ISO Abbreviation: Ulster Med J Publication Date: 1985 Aug
Date Detail:	Created Date: 1986-02-18 Completed Date: 1986-02-18 Revised Date: 2010-09-10
Medline Journal Info:	Nlm Unique ID: 0417367 Medline TA: Ulster Med J Country: NORTHERN IRELAND
Other Details:	Languages: eng Pagination: S5-19 Citation Subset: IM; Q
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MeSH Terms
Descriptor/Qualifier:	Adult Child History, 15th Century History, 18th Century History, 19th Century History, 20th Century Humans Hyperlipidemias / complications Infection / complications Kidney Failure, Acute / complications Nephrotic Syndrome / complications, history* Thrombosis / complications
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Journal Information Journal ID (nlm-ta): Ulster Med J ISSN: 0041-6193	Article Information Download PDF Print publication date: Month: 08 Year: 1985 Volume: 54 Issue: Suppl First Page: S5 Last Page: S19 ID: 2447965 PubMed Id: 3909583 PubMed Id: 3909583