Document Detail


Five clinical conundrums in the management of giant cell arteritis.
MedLine Citation:
PMID:  18037119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinicians who treat patients with giant cell arteritis (GCA) face many unresolved challenges. Visual loss still occurs in 15% to 20% of patients despite the availability of therapy for the disease that is generally effective. Aneurysm formation and large vessel stenosis are increasingly recognized complications. Substantial iatrogenic morbidity stems from glucocorticoid therapy, and recent trials have failed to identify an efficient steroid sparing agent. In this review, the authors address five major clinical conundrums in the management of GCA.
Authors:
Maria C Cid; Ana García-Martínez; Ester Lozano; Georgina Espígol-Frigolé; José Hernández-Rodríguez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Rheumatic diseases clinics of North America     Volume:  33     ISSN:  0889-857X     ISO Abbreviation:  Rheum. Dis. Clin. North Am.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-26     Completed Date:  2008-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708093     Medline TA:  Rheum Dis Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  819-34, vii     Citation Subset:  IM    
Affiliation:
Vasculitis Research Unit, Department of Internal Medicine, Hospital Clínic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. mccid@clinic.ub.es
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / therapeutic use
Aorta / pathology
Aortography
Azathioprine / administration & dosage
Dilatation, Pathologic
Giant Cell Arteritis / complications,  radiography,  therapy*
Glucocorticoids / administration & dosage
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Methotrexate / therapeutic use
Prednisone / administration & dosage
Pulse Therapy, Drug
Tomography, Spiral Computed
Vision Disorders / etiology
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Glucocorticoids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 446-86-6/Azathioprine; 53-03-2/Prednisone; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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