Document Detail

Five cases of brain injury following amniocentesis in mid-term pregnancy.
MedLine Citation:
PMID:  10981934     Owner:  NLM     Status:  MEDLINE    
This paper describes the neuroimaging and neuropathological findings in five cases of severe brain damage after traumatic mid-trimester amniocentesis, all performed between 1986 and 1994. Although fetal injury after amniocentesis has been reported, reports of brain injury are infrequent. Continuous ultrasound monitoring may reduce the risk of fetal injury but follow-up ultrasound scans can be falsely reassuring. Withdrawal of blood-stained fluid, particularly if it contains tissue fragments, should alert the operator to the possibility of fetal damage. Histological examination of such tissue fragments may confirm the nature of the fetal damage. The consequences of fetal brain injury are severe, all five of our cases showed evidence of disruption of brain development compatible with mid-term injury. Obstetricians and their patients should be aware of the small but significant risk of brain damage after mid-term amniocentesis.
M Squier; P Chamberlain; Z Zaiwalla; P Anslow; J Oxbury; S Gould; M A McShane
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  42     ISSN:  0012-1622     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-21     Completed Date:  2000-09-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  554-60     Citation Subset:  IM    
Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.
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MeSH Terms
Amniocentesis / adverse effects*,  methods
Brain / growth & development
Brain Injuries / etiology*
False Negative Reactions
Infant, Newborn
Middle Aged
Pregnancy Complications*
Pregnancy Trimester, Second
Retrospective Studies
Risk Assessment
Ultrasonography, Interventional*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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