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Five-Year Change in Morphological and Functional Alterations of the Thyroid Gland - the Study of Health in Pomerania.
MedLine Citation:
PMID:  22512530     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background. While cross-sectional data on thyroid epidemiology are common, few longitudinal data on incidence and progression of thyroid disorders exist. The aim of this study was to analyze the 5-year change and the incidence of morphological and functional alterations of the thyroid gland in a previously iodine deficient area. Methods. We used five-year follow-up data based on 2941 participants (20-79 years) of the population-based Study of Health in Pomerania (SHIP). Thyroid structure and size were measured by ultrasound. Thyroid function and serum autoantibodies to thyroperoxidase (anti TPO-Ab) were evaluated. Results. During follow-up, the median iodine-creatinine ratio decreased slightly from 134.2 to 130.4 µg/g. The mean thyroid volume non-significantly increased by 0.73 ml (CI -1.68-3.41 ml). The incidence rate of goiter was 34.0 [CI 30.7-37.7] per 1000 person years (py), the incident rate of nodules was 16.6 [CI 14.5-19.1] per 1000 py. Median serum thyrotropin levels increased slightly (0.10, CI -0.10-0.34 mIU/l). The incidence of positive anti TPO-Ab was 3.4 (CI 2.6-4.7) per 1000 py. For all thyroid parameters, the regression rates were higher than the incidence rates. Conclusions. After iodine fortification became effective in this previously iodine-deficient region, there is a negative net balance between occurring and reverting goiter and nodules. Along with balanced incidences of hyper- and hypothyroid dysfunction and the low incidence of autoimmune-related findings, these findings indicate that the current iodine status is sufficient to prevent iodine deficiency related disorders the adult population of the study region.
Authors:
Henry Völzke; Till Ittermann; Martin Albers; Nele Friedrich; Matthias Nauck; Harald Below
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  -     ISSN:  1557-9077     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Ernst Moritz Arndt University, Institute for Community Medicine, Rathenaustr. 48, Greifswald, Germany, D-17487, 00493834867707; voelzke@uni-greifswald.de.
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