Document Detail

Fitness, fatness, and systolic blood pressure: data from the Cooper Center Longitudinal Study.
MedLine Citation:
PMID:  20598988     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Modifying risk factors to delay or prevent hypertension is critical for subsequent cardiovascular risk reduction. Therefore, understanding the independent and joint associations between cardiorespiratory fitness, obesity, and systolic blood pressure (SBP) is of major significance. In this study, we assessed the relative contribution of body mass index (BMI) and cardiorespiratory fitness to SBP in a large, healthy population. METHODS: Blood pressure, BMI, and cardiorespiratory fitness were measured in 35,061 patients seen for a preventive health examination (1990 to present). BMI was treated as a continuous variable and categorized into sex-specific quartiles. Cardiorespiratory fitness was defined as time achieved during maximal exercise testing and categorized into age- and sex-adjusted quintiles. Generalized linear models were used to determine the independent contribution of fitness and BMI on systolic blood pressure estimates. RESULTS: The study group was predominately white men (69%) with an average age of 46 years. Normal-weight subjects had a mean SBP 12 mm Hg lower than in the obese (115 vs 127 mm Hg, P < .001), while being high- fit was associated 6 mm Hg difference in mean SBP comparing the highest and lowest fitness quintile (119 vs 125 mm Hg, P < .001). Normal-weight individuals with a cardiorespiratory fitness level greater than the first quintile (Q1) had the lowest mean SBP (P < .001). Both BMI and cardiorespiratory fitness were associated with SBP (P < .001 for both); however, when assessed simultaneously, BMI had a greater impact on SBP estimates than fitness. CONCLUSION: When comparing lifestyle risk factors BMI and cardiorespiratory fitness, BMI was a more important factor in predicting SBP. Importantly, only modest fitness levels among normal-weight individuals were associated with the lowest systolic blood pressure estimates.
Jennifer Chen; Sandeep Das; Carolyn E Barlow; Scott Grundy; Susan G Lakoski
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  160     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  166-70     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
UT Southwestern Medical School, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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MeSH Terms
Blood Pressure / physiology*
Body Mass Index*
Follow-Up Studies
Hypertension / epidemiology,  physiopathology,  prevention & control*
Middle Aged
Overweight / complications,  physiopathology,  rehabilitation*
Physical Fitness / physiology*
Retrospective Studies
Risk Factors
Texas / epidemiology
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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