Document Detail

Fitness conferred by replaced amino acids declines with time.
MedLine Citation:
PMID:  22628094     Owner:  NLM     Status:  MEDLINE    
The fitness landscape of a locus, the array of fitnesses conferred by its alleles, can be affected by allele replacements at other loci, in the presence of epistatic interactions between loci. In a pair of diverging homologous proteins, the initially high probability that an amino acid replacement in one of them will make it more similar to the other declines with time, implying that the fitness landscapes of homologous sites diverge. Here, we use data on within-population non-synonymous polymorphisms and on amino acid replacements between species to study the dynamics, after an amino acid replacement, of the fitness of the ancestral amino acid, and show that selection against its restoration increases with time. This effect can be owing to increase of fitness conferred by the new amino acid occupying the site, and/or to decline of fitness conferred by the replaced amino acid. We show that the fitness conferred by the replaced amino acid rapidly declines, reaching a new lower steady-state level after approximately 20 per cent of amino acids in the protein get replaced. Therefore, amino acid replacements in evolving proteins are routinely involved in negative epistatic interactions with currently absent amino acids, and chisel off the unused parts of the fitness landscape.
Sergey A Naumenko; Alexey S Kondrashov; Georgii A Bazykin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-23
Journal Detail:
Title:  Biology letters     Volume:  8     ISSN:  1744-957X     ISO Abbreviation:  Biol. Lett.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-02-11     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101247722     Medline TA:  Biol Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  825-8     Citation Subset:  IM    
Institute for Information Transmission Problems, Russian Academy of Sciences, Bolshoi Karetny per. 19, Moscow 127994, Russia.
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MeSH Terms
Amino Acids / chemistry*
Epistasis, Genetic
Evolution, Molecular
Genetic Fitness*
Insects / physiology
Models, Genetic
Polymorphism, Genetic
Selection, Genetic*
Time Factors
Vertebrates / physiology
Reg. No./Substance:
0/Amino Acids; 0/Codon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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