Document Detail


Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats.
MedLine Citation:
PMID:  19416649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conjugation of bile acids (BAs) to the amino acids taurine or glycine increases their solubility and promotes liver BA secretion. Supplementing diets with taurine or glycine modulates BA metabolism and enhances fecal BA excretion in rats. However, it is still unclear whether dietary proteins varying in taurine and glycine contents alter BA metabolism, and thereby modulate the recently discovered systemic effects of BAs. Here we show that rats fed a diet containing saithe fish protein hydrolysate (saithe FPH), rich in taurine and glycine, for 26 days had markedly elevated fasting plasma BA levels relative to rats fed soy protein or casein. Concomitantly, the saithe FPH fed rats had reduced liver lipids and fasting plasma TAG levels. Furthermore, visceral adipose tissue mass was reduced and expression of genes involved in fatty acid oxidation and energy expenditure was induced in perirenal/retroperitoneal adipose tissues of rats fed saithe FPH. Our results provide the first evidence that dietary protein sources with different amino acid compositions can modulate the level of plasma bile acids and our data suggest potential novel mechanisms by which dietary protein sources can affect energy metabolism.
Authors:
Bjørn Liaset; Lise Madsen; Qin Hao; Gabriel Criales; Gunnar Mellgren; Hanns-Ulrich Marschall; Philip Hallenborg; Marit Espe; Livar Frøyland; Karsten Kristiansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-31
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1791     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-08     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  254-62     Citation Subset:  IM    
Affiliation:
National Institute of Nutrition and Seafood Research, Box 2029 Nordnes, N-5817 Bergen, Norway. bjorn.liaset@nifes.no
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / blood*
Dietary Proteins / administration & dosage
Energy Metabolism / drug effects
Fishes
Glycine / administration & dosage
Intra-Abdominal Fat / metabolism*
Lipids / analysis
Liver / drug effects,  metabolism
Male
Mitochondria, Liver / drug effects,  metabolism
Multidrug Resistance-Associated Proteins / genetics,  metabolism
Protein Hydrolysates / administration & dosage*
RNA, Messenger / genetics,  metabolism
Rats
Rats, Wistar
Reverse Transcriptase Polymerase Chain Reaction
Taurine / administration & dosage
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Abcc4 protein, rat; 0/Bile Acids and Salts; 0/Dietary Proteins; 0/Lipids; 0/Multidrug Resistance-Associated Proteins; 0/Protein Hydrolysates; 0/RNA, Messenger; 0/Triglycerides; 107-35-7/Taurine; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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