Document Detail

Fish and omega-3 fatty acid intake in relation to circulating fibroblast growth factor 23 levels in renal transplant recipients.
MedLine Citation:
PMID:  25063539     Owner:  NLM     Status:  Publisher    
BACKGROUND AND AIMS: A high circulating fibroblast growth factor 23 (FGF23) level is an independent risk factor for cardiovascular mortality in renal transplant recipients and the general population. N-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) may contribute to cardiovascular risk reduction. We investigated whether fish and EPA-DHA intake are related to FGF23 levels in renal transplant recipients.
METHODS AND RESULTS: We performed a cross-sectional analysis in 619 stable renal transplant recipients (mean age 53 years, 57% male, estimated glomerular filtration rate [eGFR] 53 ± 20 mL/min/1.73 m(2)). Dietary intake was assessed by a 177-item food frequency questionnaire. Serum intact FGF23 was measured by ELISA. We examined differences in FGF23 levels across categories of fish and EPA-DHA intake using analysis of variance models adjusted for age, sex, dietary and lifestyle factors and key determinants of FGF23. Patients consumed on average 15 g of fish and 139 mg EPA-DHA/day. Median FGF23 was 62 pg/mL (IQR 43-98 pg/mL). Higher dietary EPA-DHA and fish intake were associated with lower serum FGF23 levels. Subgroup analyses revealed that particularly in patients with reduced renal function (eGFR <60 mL/min/1.73 m(2)), adjusted FGF23 levels (114, 79, 75 pg/mL, P = 0.0001) were inversely associated with tertiles of EPA-DHA intake. Similarly, we observed an inverse association between fish consumption and serum FGF23 levels in adjusted analyses.
CONCLUSION: A higher intake of fish and dietary n-3 fatty acids (EPA-DHA) is related to lower circulating FGF23 levels in renal transplant recipients. Further research is needed to assess the causality of this association and the clinical implications.
L C Baia; E Van den Berg; M G Vervloet; I P Heilberg; G Navis; S J L Bakker; J M Geleijnse; D Kromhout; S S Soedamah-Muthu; M H De Borst;
Related Documents :
9752649 - Spontaneous detachment of the deltoid muscle origin.
24635789 - Immunonutrition in kidney and liver transplant recipients.
10509959 - Chronic microscopic enterocolitis with severe hypokalemia responding to subtotal colect...
7781639 - Caesarean section in chronic renal failure.
2985309 - Activity of helix: destabilizing protein in lymphocytes of patients with glomerulopathi...
16811009 - Urea distribution in renal failure.
24762209 - Scoring systems predict the prognosis of acute-on-chronic hepatitis b liver failure: an...
11110679 - Engraftment and survival after unrelated-donor bone marrow transplantation: a report fr...
3902229 - Curable renal parenchymatous hypertension: current diagnosis and management.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-23
Journal Detail:
Title:  Nutrition, metabolism, and cardiovascular diseases : NMCD     Volume:  -     ISSN:  1590-3729     ISO Abbreviation:  Nutr Metab Cardiovasc Dis     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-7-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111474     Medline TA:  Nutr Metab Cardiovasc Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dietary non-enzymatic antioxidant capacity and the risk of myocardial infarction: A case-control stu...
Next Document:  Latent TB infection in newly diagnosed lung cancer patients - A multicenter prospective observationa...