Document Detail

Fish oils in cardiovascular disease.
MedLine Citation:
PMID:  2650696     Owner:  NLM     Status:  MEDLINE    
Although several studies have reported an inverse relationship between the dietary history of fish intake and the prospective incidence of death from coronary heart disease, it is unclear whether these results represent the effects of n-3 fatty acids themselves or whether they merely reflect a more fundamental alteration in diet, such as a reduction in saturated fatty acids. n-3 fatty acids alter platelet eicosanoid formation, replacing arachidonate derived thromboxane (Tx)A2 with the biologically inert TxA3. However, they are a relatively inefficient approach to platelet inhibition. This is evident from results obtained in a model of coronary thrombosis followed by thrombolysis with tissue plasminogen activator (tPA). By contrast, high doses of n-3 fatty acids (15 g day-1) significantly reduced blood pressure in mild hypertensives in a double-blind, controlled study characterized by a prolonged run-in period and adequate follow-up. Fish oils inhibit the vascular proliferative response to injury in a variety of animal models, apparently independently of their effects on lipoprotein metabolism. Recent results imply that they may selectively interfere with the vascular expression of mitogenic peptides.
G A Fitzgerald; G Braden; D J Fitzgerald; H R Knapp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of internal medicine. Supplement     Volume:  731     ISSN:  0955-7873     ISO Abbreviation:  J Intern Med Suppl     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8912975     Medline TA:  J Intern Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee.
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MeSH Terms
Arteriosclerosis / prevention & control
Blood Platelets / drug effects
Blood Pressure / drug effects
Cardiovascular Diseases / prevention & control*
Fatty Acids, Unsaturated / therapeutic use*
Fish Oils / therapeutic use*
Lipid Peroxides / biosynthesis
Platelet-Derived Growth Factor / biosynthesis
Thromboxanes / biosynthesis
Grant Support
Reg. No./Substance:
0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Lipid Peroxides; 0/Platelet-Derived Growth Factor; 0/Thromboxanes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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