Document Detail


Fish oil for the treatment of cardiovascular disease.
MedLine Citation:
PMID:  20699674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Omega-3 fatty acids, which are found abundantly in fish oil, are increasingly being used in the management of cardiovascular disease. It is clear that fish oil, in clinically used doses (typically 4 g/d of eicosapentaenoic acid and docosahexaenoic acid) reduce high triglycerides. However, the role of omega-3 fatty acids in reducing mortality, sudden death, arrhythmias, myocardial infarction, and heart failure has not yet been established. This review will focus on the current clinical uses of fish oil and provide an update on their effects on triglycerides, coronary artery disease, heart failure, and arrhythmia. We will explore the dietary sources of fish oil as compared with drug therapy, and discuss the use of fish oil products in combination with other commonly used lipid-lowering agents. We will examine the underlying mechanism of fish oil's action on triglyceride reduction, plaque stability, and effect in diabetes, and review the newly discovered anti-inflammatory effects of fish oil. Finally, we will examine the limitations of current data and suggest recommendations for fish oil use.
Authors:
Daniel Weitz; Howard Weintraub; Edward Fisher; Arthur Z Schwartzbard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Cardiology in review     Volume:  18     ISSN:  1538-4683     ISO Abbreviation:  Cardiol Rev     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-08-11     Completed Date:  2011-06-02     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  258-63     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / epidemiology,  prevention & control
Cardiovascular Diseases / drug therapy*,  epidemiology,  mortality
Death, Sudden, Cardiac / epidemiology,  prevention & control
Diabetes Mellitus / epidemiology,  prevention & control
Fatty Acids, Omega-3 / therapeutic use*
Fenofibrate / therapeutic use
Fish Oils / therapeutic use
Heart Failure / epidemiology,  prevention & control
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hypolipidemic Agents / therapeutic use
Triglycerides / metabolism
United States / epidemiology
Grant Support
ID/Acronym/Agency:
R01 HL058541/HL/NHLBI NIH HHS; R01 HL058541-12A1/HL/NHLBI NIH HHS; R01 HL58541/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Hypolipidemic Agents; 0/Triglycerides; U202363UOS/Fenofibrate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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