| Fish oil for the treatment of cardiovascular disease. | |
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MedLine Citation:
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PMID: 20699674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omega-3 fatty acids, which are found abundantly in fish oil, are increasingly being used in the management of cardiovascular disease. It is clear that fish oil, in clinically used doses (typically 4 g/d of eicosapentaenoic acid and docosahexaenoic acid) reduce high triglycerides. However, the role of omega-3 fatty acids in reducing mortality, sudden death, arrhythmias, myocardial infarction, and heart failure has not yet been established. This review will focus on the current clinical uses of fish oil and provide an update on their effects on triglycerides, coronary artery disease, heart failure, and arrhythmia. We will explore the dietary sources of fish oil as compared with drug therapy, and discuss the use of fish oil products in combination with other commonly used lipid-lowering agents. We will examine the underlying mechanism of fish oil's action on triglyceride reduction, plaque stability, and effect in diabetes, and review the newly discovered anti-inflammatory effects of fish oil. Finally, we will examine the limitations of current data and suggest recommendations for fish oil use. |
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Authors:
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Daniel Weitz; Howard Weintraub; Edward Fisher; Arthur Z Schwartzbard |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Cardiology in review Volume: 18 ISSN: 1538-4683 ISO Abbreviation: Cardiol Rev Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-08-11 Completed Date: 2011-06-02 Revised Date: 2011-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9304686 Medline TA: Cardiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 258-63 Citation Subset: IM |
Affiliation:
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Department of Medicine, Leon H. Charney Division of Cardiology, NYU Langone Medical Center, New York, NY 10016, USA. Weitz@nyumc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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epidemiology,
prevention & control Cardiovascular Diseases / drug therapy*, epidemiology, mortality Death, Sudden, Cardiac / epidemiology, prevention & control Diabetes Mellitus / epidemiology, prevention & control Fatty Acids, Omega-3 / therapeutic use* Fenofibrate / therapeutic use Fish Oils / therapeutic use Heart Failure / epidemiology, prevention & control Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Hypolipidemic Agents / therapeutic use Triglycerides / metabolism United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL058541-12A1/HL/NHLBI NIH HHS; R01 HL58541/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Hypolipidemic Agents; 0/Triglycerides; 49562-28-9/Fenofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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