Document Detail

Fish oil-supplemented parenteral nutrition in severe acute pancreatitis patients and effects on immune function and infectious risk: a randomized controlled trial.
MedLine Citation:
PMID:  19568921     Owner:  NLM     Status:  MEDLINE    
The human leukocyte antigen (HLA)-DR expression on monocytes and plasma Interleukin (IL)-10 levels are key indicators of immune response during the acute phase of severe acute pancreatitis (SAP). We designed a pilot study to investigate whether omega-3 fatty acids (FAs) supplemented parenteral nutrition (PN) could improve immune response in SAP patients. Fifty-six SAP patients were enrolled (28 patients in each group) and received isocaloric and isonitrogenous parenteral nutrition, providing 1.0 g/kg/day standard soybean-oil based fat (omega-6 FAs group) or 0.8 g/kg/day soybean oil +0.2 g/kg/day omega-3 FAs based fat (omega-3 FAs group). IL-10, HLA-DR and the ratio of CD4(+) to CD8(+) were determined before PN treatment and on day 6 after starting PN. The infection and surgery rates were recorded until hospital discharge. A significant IL-10 increase was associated with the administration of omega-3 FAs (p = 0.04, vs omega-6 FAs group). Monocyte HLA-DR expression improved in both groups after 5 days of PN treatment. This increase was significantly higher in the omega-3 FAs group compared to omega-6 FAs (p = 0.01). There was no significant difference of CD4(+)/CD8(+), infection and surgery rates between the two groups. In conclusion, omega-3 FAs supplemented PN can elevate the IL-10 level and HLA-DR expression in SAP patients. A larger trial is required to see whether omega-3 FAs supplemented PN treatment in SAP patients would result in better clinical outcomes than omega-6 FAs.
Xinying Wang; Weiqin Li; Feng Zhang; Liya Pan; Ning Li; Jieshou Li
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation     Volume:  32     ISSN:  1573-2576     ISO Abbreviation:  Inflammation     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-02     Completed Date:  2010-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  304-9     Citation Subset:  IM    
Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
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MeSH Terms
Acute Disease
Dietary Supplements*
Double-Blind Method
Enteral Nutrition / methods
Fatty Acids, Omega-3 / administration & dosage*
Fatty Acids, Omega-6 / administration & dosage
Fish Oils / administration & dosage*
Immune System / drug effects*,  metabolism
Infection / therapy
Interleukin-10 / biosynthesis,  blood
Middle Aged
Pancreatitis / therapy
Parenteral Nutrition / methods*
Pilot Projects
Risk Factors
Severity of Illness Index
Soybean Oil / administration & dosage
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fish Oils; 130068-27-8/Interleukin-10; 8001-22-7/Soybean Oil

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