| Fish oil-supplemented parenteral nutrition in severe acute pancreatitis patients and effects on immune function and infectious risk: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 19568921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human leukocyte antigen (HLA)-DR expression on monocytes and plasma Interleukin (IL)-10 levels are key indicators of immune response during the acute phase of severe acute pancreatitis (SAP). We designed a pilot study to investigate whether omega-3 fatty acids (FAs) supplemented parenteral nutrition (PN) could improve immune response in SAP patients. Fifty-six SAP patients were enrolled (28 patients in each group) and received isocaloric and isonitrogenous parenteral nutrition, providing 1.0 g/kg/day standard soybean-oil based fat (omega-6 FAs group) or 0.8 g/kg/day soybean oil +0.2 g/kg/day omega-3 FAs based fat (omega-3 FAs group). IL-10, HLA-DR and the ratio of CD4(+) to CD8(+) were determined before PN treatment and on day 6 after starting PN. The infection and surgery rates were recorded until hospital discharge. A significant IL-10 increase was associated with the administration of omega-3 FAs (p = 0.04, vs omega-6 FAs group). Monocyte HLA-DR expression improved in both groups after 5 days of PN treatment. This increase was significantly higher in the omega-3 FAs group compared to omega-6 FAs (p = 0.01). There was no significant difference of CD4(+)/CD8(+), infection and surgery rates between the two groups. In conclusion, omega-3 FAs supplemented PN can elevate the IL-10 level and HLA-DR expression in SAP patients. A larger trial is required to see whether omega-3 FAs supplemented PN treatment in SAP patients would result in better clinical outcomes than omega-6 FAs. |
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Authors:
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Xinying Wang; Weiqin Li; Feng Zhang; Liya Pan; Ning Li; Jieshou Li |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Inflammation Volume: 32 ISSN: 1573-2576 ISO Abbreviation: Inflammation Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-02 Completed Date: 2010-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600105 Medline TA: Inflammation Country: United States |
Other Details:
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Languages: eng Pagination: 304-9 Citation Subset: IM |
Affiliation:
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Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. wxinying@263.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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APACHE Acute Disease Adult Dietary Supplements* Double-Blind Method Enteral Nutrition / methods Fatty Acids, Omega-3 / administration & dosage* Fatty Acids, Omega-6 / administration & dosage Female Fish Oils / administration & dosage* Humans Immune System / drug effects*, metabolism Infection / therapy Interleukin-10 / biosynthesis, blood Male Middle Aged Pancreatitis / therapy Parenteral Nutrition / methods* Pilot Projects Risk Factors Severity of Illness Index Soybean Oil / administration & dosage Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fish Oils; 130068-27-8/Interleukin-10; 8001-22-7/Soybean Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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