| Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. | |
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MedLine Citation:
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PMID: 19489765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maternal intake of omega-3 (omega-3) polyunsaturated fatty acids (PUFAs) during pregnancy has decreased, possibly contributing to a current increased risk of childhood allergy. Aim: To describe the effects of maternal omega-3 long-chain PUFA supplementation during pregnancy and lactation on the incidence of allergic disease in infancy. Methods: One hundred and forty-five pregnant women, affected by allergy themselves or having a husband or previous child with allergies, were included in a randomized placebo-controlled trial. Daily maternal supplementation with either 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid or placebo was given from the 25(th) gestational week to average 3-4 months of breastfeeding. Skin prick tests, detection of circulating specific immunoglobulin E (IgE) antibodies and clinical examinations of the infants were performed. Results: The period prevalence of food allergy was lower in the omega-3 group (1/52, 2%) compared to the placebo group (10/65, 15%, p < 0.05) as well as the incidence of IgE-associated eczema (omega-3 group: 4/52, 8%; placebo group: 15/63, 24%, p < 0.05). Conclusion: Maternal omega-3 fatty acid supplementation may decrease the risk of food allergy and IgE-associated eczema during the first year of life in infants with a family history of allergic disease. |
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Authors:
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Catrin Furuhjelm; Kristina Warstedt; Johanna Larsson; Mats Fredriksson; Malin Fagerås Böttcher; Karin Fälth-Magnusson; Karel Duchén |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-06-01 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 98 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-13 Completed Date: 2009-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1461-7 Citation Subset: IM |
Affiliation:
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Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. catrin.furuhjelm@lio.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Breast Feeding Chi-Square Distribution Dietary Supplements* Double-Blind Method Eczema / epidemiology, immunology, prevention & control* Fatty Acids, Omega-3 / administration & dosage* Female Food Hypersensitivity / epidemiology, immunology, prevention & control* Humans Immunity, Maternally-Acquired* Immunoglobulin E / blood Infant Lactation / immunology Logistic Models Maternal Nutritional Physiological Phenomena Pregnancy Prevalence Risk Factors Skin Tests |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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