| Fish oil prevents high-saturated fat diet-induced impairments in adiponectin and insulin response in rodent soleus muscle. | |
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MedLine Citation:
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PMID: 22204953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High saturated fatty acid (SFA) diets contribute to the development of insulin resistance, whereas fish oil-derived n-3 polyunsaturated fatty acids (PUFA) increase the secretion of adiponectin (Ad), an adipocyte-derived protein that stimulates fatty acid oxidation (FAO) and improves skeletal muscle insulin response. We sought to determine whether fish oil could prevent and/or restore high SFA diet-induced impairments in Ad and insulin response in soleus muscle. Sprague-Dawley rats were fed 1) a low-fat control diet (CON group), 2) high-SFA diet (SFA group), or 3) high SFA with n-3 PUFA diet (SFA/n-3 PUFA group). At 4 wk, CON and SFA/n-3 PUFA animals were terminated, and SFA animals were either terminated or fed SFA or SFA/n-3 PUFA for an additional 2 or 4 wk. The effect of diet on Ad-stimulated FAO, insulin-stimulated glucose transport, and expression of Ad, insulin and inflammatory signaling proteins was determined in the soleus muscle. Ad stimulated FAO in CON and 4 wk SFA/n-3 PUFA (+36%, +39%, respectively P ≤ 0.05) only. Insulin increased glucose transport in CON, 4 wk SFA/n-3 PUFA, and 4 wk SFA + 4 wk SFA/n-3 PUFA (+82%, +33%, +25%, respectively P ≤ 0.05); this effect was lost in all other groups. TLR4 expression was increased with 4 wk of SFA feeding (+24%, P ≤ 0.05), and this was prevented in 4 wk SFA/n-3 PUFA. Suppressor of cytokine signaling-3 expression was increased in SFA and SFA/n-3 PUFA (+33 and +18%, respectively, P ≤ 0.05). Our results demonstrate that fish oil can prevent high SFA diet-induced impairments in both Ad and insulin response in soleus muscle. |
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Authors:
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Justine M Tishinsky; Roberto A Gulli; Kerry L Mullen; David J Dyck; Lindsay E Robinson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-12-28 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 302 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-06 Completed Date: 2012-05-03 Revised Date: 2012-05-23 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R598-605 Citation Subset: IM |
Affiliation:
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Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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metabolism* Animals Body Mass Index Dietary Fats / adverse effects, pharmacology* Fatty Acids / adverse effects, pharmacology* Fatty Acids, Unsaturated / pharmacology Female Fish Oils / pharmacology* Glucose / metabolism Insulin / metabolism* Models, Animal Muscle, Skeletal / drug effects*, metabolism* Proto-Oncogene Proteins c-akt / metabolism Rats Rats, Sprague-Dawley Suppressor of Cytokine Signaling Proteins / metabolism Toll-Like Receptor 4 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Insulin; 0/Socs3 protein, rat; 0/Suppressor of Cytokine Signaling Proteins; 0/Tlr4 protein, rat; 0/Toll-Like Receptor 4; 50-99-7/Glucose; EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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