Document Detail

Fish oil n-3 polyunsaturated fatty acids selectively affect plasma cytokines and decrease illness in Thai schoolchildren: a randomized, double-blind, placebo-controlled intervention trial.
MedLine Citation:
PMID:  18930251     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether very long-chain n-3 polyunsaturated fatty acids (PUFAs) affect illness and selected plasma cytokines in schoolchildren. STUDY DESIGN: Thai schoolchildren aged 9 to 12 years consumed milk containing placebo (soybean) oil (n = 86) or fish oil (n = 94) on 5 days per week for 6 months; the latter provided 200 mg eicosapentaenoic acid plus 1 g docosahexaenoic acid daily. Episodes and duration of illness were recorded, and plasma interleukin (IL)-2 receptor, IL-6, IL-10, and transforming growth factor (TGF)-beta1 concentrations and the fatty acid profile of plasma phosphatidylcholine determined. RESULTS: After intervention, very long-chain n-3 PUFAs were higher in plasma phosphatidylcholine in the fish oil group than in the placebo group (P < .001). The fish oil group showed fewer episodes (P = .014) and shorter duration (P = .024) of illness (mainly upper respiratory tract) than the placebo group. Plasma IL-2 receptor, IL-10, and IL-6 were not affected by either treatment. Plasma TGF-beta1 increased in both groups, but the increase was smaller in the fish oil group, and at the end of supplementation TGF-beta1 concentration was lower in the fish oil group (P < .001). CONCLUSIONS: Very long-chain n-3 PUFAs reduce illness, mainly infections, in healthy Thai schoolchildren.
Alice Thienprasert; Suched Samuhaseneetoo; Kathryn Popplestone; Annette L West; Elizabeth A Miles; Philip C Calder
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2008-10-18
Journal Detail:
Title:  The Journal of pediatrics     Volume:  154     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2009-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-5     Citation Subset:  AIM; IM    
Faculty of Science, Silpakorn University, Nakornpathom, Thailand.
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MeSH Terms
Cytokines / blood,  drug effects*
Docosahexaenoic Acids / administration & dosage*,  blood
Double-Blind Method
Eicosapentaenoic Acid / administration & dosage*,  blood
Interleukin-10 / blood
Interleukin-6 / blood
Phosphatidylcholines / blood
Receptors, Interleukin-2 / blood,  drug effects
Respiratory Tract Infections / blood,  prevention & control*
Transforming Growth Factor beta1 / blood,  drug effects
Treatment Outcome
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Interleukin-6; 0/Phosphatidylcholines; 0/Receptors, Interleukin-2; 0/Transforming Growth Factor beta1; 130068-27-8/Interleukin-10; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

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