Document Detail

Fish oil induced increase in walking distance, but not ankle brachial pressure index, in peripheral arterial disease is dependent on both body mass index and inflammatory genotype.
MedLine Citation:
PMID:  17600695     Owner:  NLM     Status:  MEDLINE    
Peripheral arterial disease (PAD) is an atherosclerotic disease. Evidence suggests that atherosclerosis is an inflammatory condition and long chain n-3 fatty acids, found in oily fish and fish oils, have been shown to reduce inflammation. Genetic and lifestyle factors such as body mass index (BMI) also influence inflammation. In this study we have examined the effect of fish oil in patients with claudication secondary to PAD. Fish oil supplementation, providing 1g EPA and 0.7 g DHA per day for 12 weeks, increased walking distance on a treadmill set at 3.2 km/h with a 7% incline. Walking distance to first pain increased from 76.2+/-8.5 m before fish oil to 140.6+/-25.5 m after fish oil (mean+/-SEM, p=0.004) and total distance walked increased from 160.0+/-21.5 m before fish oil to 242.1+/-34.5 m after fish oil (p=0.002). Fish oil supplementation also improved ankle brachial pressure index (ABPI) from 0.599+/-0.017 before fish oil to 0.776+/-0.030 after fish oil (p<0.001). The increase in walking distance was dependent on both BMI and genotype for single nucleotide polymorphisms in the genes encoding the pro-inflammatory cytokines tumour necrosis factor-alpha and interleukin (IL)-1beta and the anti-inflammatory cytokine IL-10 (detected using amplification refractory mutation system polymerase chain reaction). Neither BMI nor any of the genotypes examined affected the ability of fish oil to increase ABPI. The mechanisms by which fish oil affects walking distance and ABPI do not appear to be the same.
Jacqueline Madden; Andreas Brunner; Neville D Dastur; Rebecca M Tan; Gerard B Nash; G Ed Rainger; Cliff P Shearman; Philip C Calder; Robert F Grimble
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-27
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  76     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-30     Completed Date:  2007-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  331-40     Citation Subset:  IM    
Institute of Human Nutrition, School of Medicine, University of Southampton, and Department of Vascular Surgery, Southampton General Hospital, Southampton, UK.
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MeSH Terms
Aged, 80 and over
Ankle / blood supply
Blood Pressure / drug effects*
Body Mass Index*
Cytokines / genetics
Dietary Fats, Unsaturated / therapeutic use
Dietary Supplements
Fish Oils / therapeutic use*
Inflammation / genetics*
Intermittent Claudication / complications,  drug therapy
Middle Aged
Peripheral Vascular Diseases / complications,  drug therapy*,  genetics*
Phospholipids / blood
Polymorphism, Genetic
Waist-Hip Ratio
Reg. No./Substance:
0/Cytokines; 0/Dietary Fats, Unsaturated; 0/Fish Oils; 0/Phospholipids

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