Document Detail

Fish oil feeding increases gut contractility in spontaneous hypertensive rat (SHR) model.
MedLine Citation:
PMID:  15023694     Owner:  NLM     Status:  In-Data-Review    
Background - In a previous study we observed an apparent depression in prostanoid-induced contractility of the gut in the SHR compared to the normotensive (WKY) rat. Objective - To determine if diets containing n-3 polyunsaturated fatty acids (PUFA) can overcome the defect in prostanoid-induced contractility in the SHR ileum. Design - Twelve week old SHR were fed diets for 12 weeks containing 5% fat as saturated fat, canola oil, or fish oil and compared with WKY control. Contractility of isolated ileal and colonic tissue was determined in an organ bath system in response to muscarinic and eicosanoid stimulators of gut isometric contraction. Outcomes - As previously demonstrated, there was a significantly depressed response in the SHR ileum to PGE(2) and PGF(2alpha ) compared to the WKY. Compared to the other diets, only fish oil supplementation resulted in a significant increase in maximal ileal contraction in response to acetylcholine and prostaglandins that was positively correlated with an increase in long chain (LC) n-3 PUFA (eicosapentaenoic [EPA] and docosahexaenoic acid [DHA]) in gut tissue. However, the canola diet rich in n-3 18:3 (alpha linoleic acid [ALA]) did not result in an increase in tissue LC n-3 PUFA or changes in contractility. Conclusions - Fish oil supplementation resulted in an increase of gut tissue LC n-3 PUFA content, increased ileal contractility and reversal of the depressed gut contractility response to prostanoids in SHR. Since prostaglandins are involved in homeostasis of gut integrity and contractility, these findings may be applicable to bowel health in regard to normal and disease states.
G S Patten; M Y Abeywardena
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asia Pacific journal of clinical nutrition     Volume:  12 Suppl     ISSN:  0964-7058     ISO Abbreviation:  Asia Pac J Clin Nutr     Publication Date:  2003  
Date Detail:
Created Date:  2004-03-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440304     Medline TA:  Asia Pac J Clin Nutr     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  S64     Citation Subset:  IM    
CSIRO Health Sciences and Nutrition, Adelaide, SA 5000.
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