Document Detail


Fish oil fatty acids as cardiovascular drugs.
MedLine Citation:
PMID:  18220934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Starting in the 1970s the hypothesis that the low mortality from coronary heart disease among the Greenland Eskimos was due to their high consumption of n-3 fish oil fatty acids, initiated many studies to find if the n-3 polyunsaturated fatty acids in fish oils (PUFAs) could prevent cardiac atherosclerosis. To date this possibility has not achieved clinical recognition. The recent literature shows an increase of intervention studies to learn if the fish oil fatty acids can reduce mortality from sudden cardiac death, and the mechanism(s) of such a protective effect. Indeed the most definite beneficial cardiac action of these n-3 PUFAs seems now to be their ability in the short term to prevent sudden cardiac death. It is apparent that over long periods of time the n-3 fish oil fatty acids also prevent atherosclerosis. Definition of the fatty acids to which I will be referring in the text: n-6 (omega-6) polyunsaturated fatty acids; linoleic acid (18:2n-6, LA); arachidonic acid (C20:4n-6, AA). n-3 (omega-3) fatty acids; alpha-linolenic acid (18:3n-3, ALA); eicosapentaenoic acid (20:5n-3, EPA); docosahexaenoic acid (C22:6n-3, DHA). The bold, underlined abbreviation will appear in the text to identify the fatty acid being discussed.
Authors:
Alexander Leaf; Jing X Kang; Yong-Fu Xiao
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current vascular pharmacology     Volume:  6     ISSN:  1570-1611     ISO Abbreviation:  Curr Vasc Pharmacol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-28     Completed Date:  2008-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157208     Medline TA:  Curr Vasc Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
Affiliation:
Departments of Medicine, aMassachusetts General Hospital, Boston, MA, USA. aleaf@partners.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Atherosclerosis / prevention & control
Calcium Channels, L-Type / drug effects
Cardiovascular Agents / therapeutic use*
Cardiovascular Diseases / drug therapy*
Cells, Cultured
Death, Sudden, Cardiac / prevention & control
Dogs
Electrophysiology
Fatty Acids, Omega-3 / therapeutic use*
Fish Oils / therapeutic use*
Humans
Myocytes, Cardiac / drug effects
Rats
Chemical
Reg. No./Substance:
0/Calcium Channels, L-Type; 0/Cardiovascular Agents; 0/Fatty Acids, Omega-3; 0/Fish Oils

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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