Document Detail

Fish oil containing phytosterol esters alters blood lipid profiles and left ventricle generation of thromboxane a(2) in adult guinea pigs.
MedLine Citation:
PMID:  12042424     Owner:  NLM     Status:  MEDLINE    
This study was designed to investigate the lipid-lowering ability of a novel dietary ingredient composed of phytosterols esterified to (n-3) polyunsaturated fatty acids (PUFA) [PS(n-3)]. Adult guinea pigs were fed a test diet supplemented with PS(n-3) (25 g/kg) and corn oil (CO, 5 g/kg), whereas the diet fed to control guinea pigs was supplemented with CO only (30 g/kg). Cholesterol was added to both diets (0.8 g/kg). After 3-4 wk of consuming the diets, serum total cholesterol (TC) and triacylglycerol (TAG) in the PS(n-3) group were 36 and 29% lower, respectively, than levels in controls (P < 0.05). The lower TC levels in the PS(n-3) group reflected a 38% reduction in non-HDL cholesterol (non-HDL-C), whereas the HDL-C concentration was unaffected. Analysis of cardiac left ventricle indicated that generation of the proaggregatory, arrhythmic eicosanoid, thromboxane A(2), was >60% lower in the PS(n-3)-supplemented guinea pigs than in CO controls (P < 0.001). This study demonstrates that the TAG-lowering and eicosanoid-modifying properties of the fish oil (n-3) PUFA are retained when they are provided in the diet in ester linkage with hypocholesterolemic phytosterols.
H Stephen Ewart; Laura K Cole; Jaroslav Kralovec; Heather Layton; Jonathan M Curtis; Jeffrey L C Wright; Mary G Murphy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  132     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-03     Completed Date:  2002-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1149-52     Citation Subset:  IM    
Ocean Nutrition Canada, Limited, Halifax, Nova Scotia, Canada.
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MeSH Terms
Cholesterol / blood
Cholesterol, HDL / metabolism
Corn Oil
Fatty Acids, Omega-3 / administration & dosage,  pharmacology
Fish Oils / chemistry*,  pharmacology
Guinea Pigs
Lipid Metabolism
Lipids / blood*
Myocardium / metabolism
Phytosterols / administration & dosage*,  pharmacology
Thromboxane A2 / biosynthesis*
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Lipids; 0/Phytosterols; 0/Triglycerides; 57-88-5/Cholesterol; 57576-52-0/Thromboxane A2; 8001-30-7/Corn Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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