Document Detail

Fish oil concentrate delays sensitivity to thermal nociception in mice.
MedLine Citation:
PMID:  21345372     Owner:  NLM     Status:  MEDLINE    
Fish oil has been used to alleviate pain associated with inflammatory conditions such as rheumatoid arthritis. The anti-inflammatory property of fish oil is attributed to the n-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid. Contrarily, vegetable oils such as safflower oil are rich in n-6 fatty acids which are considered to be mediators of inflammation. This study investigates the effect of n-3 and n-6 fatty acids rich oils as dietary supplements on the thermally induced pain sensitivity in healthy mice. C57Bl/6J mice were fed diet containing regular fish oil, concentrated fish oil formulation (CFO) and safflower oil (SO) for 6 months. Pain sensitivity was measured by Plantar test and was correlated to the expression of acid sensing ion channels (ASICs), transient receptor potential vanilloid 1 (TRPV1) and c-fos in dorsal root ganglion cells. Significant delay in sensitivity to thermal nociception was observed in mice fed CFO compared to mice fed SO (p<0.05). A significant diminution in expression of ion channels such as ASIC1a (64%), ASIC13 (37%) and TRPV1 (56%) coupled with reduced expression of c-fos, a marker of neuronal activation, was observed in the dorsal root ganglion cells of mice fed CFO compared to that fed SO. In conclusion, we describe here the potential of fish oil supplement in reducing sensitivity to thermal nociception in normal mice.
Jyothi M Veigas; Paul J Williams; Ganesh Halade; Mizanur M Rahman; Toshiyuki Yoneda; Gabriel Fernandes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-02-21
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  63     ISSN:  1096-1186     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-25     Completed Date:  2011-08-16     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Fatty Acids, Omega-3 / therapeutic use*
Fatty Acids, Omega-6 / therapeutic use*
Fish Oils / therapeutic use*
Ganglia, Spinal / cytology
Mice, Inbred C57BL
Pain / diet therapy*
Proto-Oncogene Proteins c-fos / immunology
Safflower Oil / therapeutic use
Grant Support
AT 004259-02/AT/NCCAM NIH HHS; R01 AT004259/AT/NCCAM NIH HHS; R01 AT004259-05/AT/NCCAM NIH HHS
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fish Oils; 0/Proto-Oncogene Proteins c-fos; 8001-23-8/Safflower Oil

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