Document Detail


Fish in the matrix: motor learning in a virtual world.
MedLine Citation:
PMID:  23355810     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
One of the large remaining challenges in the field of zebrafish neuroscience is the establishment of techniques and preparations that permit the recording and perturbation of neural activity in animals that can interact meaningfully with the environment. Since it is very difficult to do this in freely behaving zebrafish, I describe here two alternative approaches that meet this goal via tethered preparations. The first uses head-fixation in agarose in combination with online imaging and analysis of tail motion. In the second method, paralyzed fish are suspended with suction pipettes in mid-water and nerve root recordings serve as indicators for intended locomotion. In both cases, fish can be immersed into a virtual environment and allowed to interact with this virtual world via real or fictive tail motions. The specific examples given in this review focus primarily on the role of visual feedback~- but the general principles certainly extend to other modalities, including proprioception, hearing, balance, and somatosensation.
Authors:
Florian Engert
Publication Detail:
Type:  Journal Article     Date:  2013-01-25
Journal Detail:
Title:  Frontiers in neural circuits     Volume:  6     ISSN:  1662-5110     ISO Abbreviation:  Front Neural Circuits     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-01-29     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101477940     Medline TA:  Front Neural Circuits     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  125     Citation Subset:  -    
Affiliation:
Harvard University Cambridge, MA, USA.
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