Document Detail


Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis.
MedLine Citation:
PMID:  22682084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND & AIMS: While marine omega-3 fatty acids have been associated with a lower mortality in heart failure patients, data on omega-3 and incident heart failure are inconsistent. We systematically reviewed the evidence on the association of omega-3 fatty acids and fish intake with the incidence of heart failure in this meta-analysis.
METHODS: We identified relevant studies by searching MEDLINE and EMBASE databases up to August 31, 2011 without restrictions and by reviewing reference lists from retrieved articles.
RESULTS: A total of 176,441 subjects and 5480 incident cases of heart failure from 7 prospective studies were included in this analysis. Using random effect model, the pooled relative risk for heart failure comparing the highest to lowest category of fish intake was 0.85 (95% CI; 0.73-0.99), p = 0.04; corresponding value for marine omega-3 fatty acids was 0.86 (0.74-1.00), p = 0.05. There was no evidence for heterogeneity across studies of fish consumption (I(2) = 8%). In contrast, there was modest heterogeneity for omega-3 fatty acid analysis (I(2) = 44%). Lastly, there was no evidence for publication bias.
CONCLUSIONS: This meta-analysis is consistent with a lower risk of heart failure with intake of marine omega-3 fatty acids. These observational findings should be confirmed in a large randomized trial.
Authors:
Luc Djoussé; Akintunde O Akinkuolie; Jason H Y Wu; Eric L Ding; J Michael Gaziano
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Review     Date:  2012-06-06
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  31     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-28     Completed Date:  2013-05-09     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  846-53     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Fatty Acids, Omega-3 / administration & dosage*,  blood
Fishes
Heart Failure / epidemiology*
Humans
Incidence
Risk Factors
Seafood*
Grant Support
ID/Acronym/Agency:
1R01 HL092946/HL/NHLBI NIH HHS; R01 HL092946/HL/NHLBI NIH HHS; R01HL09246S1/HL/NHLBI NIH HHS; T32 HL007575/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3
Comments/Corrections
Comment In:
Clin Nutr. 2013 Aug;32(4):661   [PMID:  23676651 ]
Clin Nutr. 2013 Aug;32(4):660   [PMID:  23683862 ]

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