| Fish Oil Supplementation Reduces Cachexia and Tumor Growth While Improving Renal Function in Tumor-Bearing Rats. | |
| | |
MedLine Citation:
|
PMID: 23015313 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The objective of the present work was to study the renal function of healthy and tumor-bearing rats chronically supplemented with fish oil (FO), a source of n-3 polyunsaturated fatty acids. Weanling male rats were divided in two groups, one control (C) and another orally supplemented for 70 days with FO (1 g/kg body weight). After this time, half the animals of each group were injected in the right flank with a suspension of Walker 256 tumor cells (W and WFO). The W group had less proteinemia reflecting cachectic proteolysis, FO reversed this fact. Tumor weight gain was also reduced in WFO. Glomerular filtration rate (GFR) was not different in FO or W compared to C, but was higher in WFO. Renal plasma flow (RPF) was higher in the FO supplemented groups. The W group had lower plasma osmolality than the C group, but FO supplementation resulted in normalization of this parameter. Fractional sodium excretion (FE(Na+)) of FO rats was similar to C. Proximal Na(+) reabsorption, evaluated by lithium clearance, was similar among the groups. Urinary thromboxane B(2) (TXB(2)) excretion was lower in the supplemented groups. The number of macrophages in renal tissue was higher in W compared to C rats, but was lower in WFO rats compared to W rats. In conclusion, FO supplementation resulted in less tumor growth and cachexia, and appeared to be renoprotective, as suggested by higher RPF and GFR. |
| | |
Authors:
|
Isabela Coelho; Fernando Casare; Danielle C T Pequito; Gina Borghetti; Ricardo K Yamazaki; Gleisson A P Brito; Marcelo Kryczyk; Luiz Claudio Fernandes; Terezila M Coimbra; Ricardo Fernandez |
Related Documents
:
|
9059543 - Ramipril therapy improves arterial dilation in experimental hypertension. 16128913 - The effects of superoxide anion generators on responses to exogenous nitric oxide and n... 652833 - Methylazoxymethanol acetate: effect of postnatal injection on brain amines and behavior. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
|
Title: Lipids Volume: - ISSN: 1558-9307 ISO Abbreviation: Lipids Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0060450 Medline TA: Lipids Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Departamento de Fisiologia, Setor de Ciências Biológicas, Universidade Federal do Paraná (UFPR) Centro Politécnico s/n.-Jd. das Américas, Post Box 19031, Curitiba, PR, 81531-990, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fast Transmethylation of Serum Lipids Using Microwave Irradiation.
Next Document: Feeding disorders of early childhood: An empirical study of diagnostic subtypes.