Document Detail

Fish oil and neurovascular control in humans.
MedLine Citation:
PMID:  22707560     Owner:  NLM     Status:  MEDLINE    
The antihypertensive influence of fish oil is controversial, and the mechanisms remain unclear. Because the inverse relation between fish oil and hypertension appears to be partially dependent on the degree of hypertension, we tested the hypothesis that fish oil would elicit more dramatic reductions in mean arterial pressure (MAP) and muscle sympathetic nerve activity (MSNA) in prehypertensive (PHT) compared with normotensive (NT) subjects. Resting MAP, MSNA, and heart rate (HR) were examined before and after 8 wk of fish oil (9 g/day; 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid) or placebo (olive oil; 9 g/day) in 38 NT (19 fish oil; 19 placebo) and 29 PHT (15 fish oil; 14 placebo) volunteers. Fish oil did not alter resting MAP, MSNA, or HR in either NT (80 ± 1 to 80 ± 1 mmHg; 11 ± 2 to 10 ± 1 bursts/min; 71 ± 2 to 71 ± 2 beats/min) or PHT (88 ± 2 to 87 ± 1 mmHg; 11 ± 2 to 10 ± 2 bursts/min; 73 ± 2 to 73 ± 2 beats/min) subjects. When NT and PHT groups were consolidated, analysis of covariance confirmed that pretreatment resting MAP was not associated with changes in MSNA after fish oil. In contrast, pretreatment resting HR was correlated with changes in MSNA (r = 0.47; P = 0.007) and MAP (r = 0.42; P < 0.007) after fish oil but not placebo. In conclusion, fish oil did not alter sympathetic neural control in NT or PHT subjects. However, our findings suggest that fish oil is associated with modest sympathoinhibition in individuals with higher resting heart rates, a finding that is consistent with a recent meta-analysis examining the relations among fish oil, HR, and the risk of cardiovascular disease.
Jason R Carter; Christopher E Schwartz; Huan Yang; Michael J Joyner
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-06-15
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2012-10-26     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H450-6     Citation Subset:  IM    
Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, Michigan 49931, USA.
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MeSH Terms
Analysis of Variance
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects*
Dietary Supplements*
Docosahexaenoic Acids / therapeutic use*
Double-Blind Method
Eicosapentaenoic Acid / therapeutic use*
Heart Rate
Muscle, Skeletal / innervation*
Prehypertension / drug therapy*,  physiopathology
Sympathetic Nervous System / drug effects*,  physiopathology
Time Factors
Treatment Outcome
Young Adult
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

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