| First use of preimplantation genotyping in prevention of recurrent diandric complete hydatidiform mole. | |
| | |
MedLine Citation:
|
PMID: 19712559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Complete hydatidiform moles have a diploid chromosome constitution, generally with only paternal genetic material present (diandry). Diandric complete moles are thought to arise either by fertilization of an anucleate oocyte by two spermatozoa or, more commonly, doubling of a single sperm genotype. Molar pregnancies are usually sporadic, and may be accompanied by malignant transformation; however, recurrence is associated with increased risk of further affected pregnancies and of persistent trophoblastic neoplasia or choriocarcinoma. This study presents the first use of preimplantation genotyping to ensure biparental inheritance in a woman presenting with recurrent diandric complete hydatidiform mole. Following an IVF cycle, a single cell from each of 11 embryos was tested by whole genome amplification and genotyping at 16 different simple tandem repeat loci. All embryos showed normal biparental inheritance; one blastocyst was transferred, resulting in the delivery of healthy monozygotic twin girls. |
| | |
Authors:
|
C Mackie Ogilvie; P J Renwick; Y Khalaf; P R Braude |
Related Documents
:
|
19066229 - Nlrp7 mutations in women with diploid androgenetic and triploid moles: a proposed mecha... 22431389 - Multilevel regulation of steroid synthesis and metabolism in the bovine placenta. 11054579 - Diploid/triploid mosaic placenta with fetus. towards a better understanding of 'partial... 8397359 - Identification of the pregnancy responsible for gestational trophoblastic disease by dn... 20103799 - Clinical findings of multiple pregnancy with a complete hydatidiform mole and coexistin... 8381709 - Diagnosis and management of gestational trophoblastic disease. 18046009 - Lamotrigine in pregnancy: clearance, therapeutic drug monitoring, and seizure frequency. 21985759 - Does light alcohol consumption during pregnancy improve offspring's cognitive development? 20579959 - Contemporary management of monochorionic diamniotic twins: outcomes and delivery recomm... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Reproductive biomedicine online Volume: 19 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2009 Aug |
Date Detail:
|
Created Date: 2009-08-28 Completed Date: 2009-11-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
|
Languages: eng Pagination: 224-7 Citation Subset: IM |
Affiliation:
|
Genetics Centre, Guy's and St Thomas' Hospital NHS Foundation Trust, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blastocyst* Female Genotype Humans Hydatidiform Mole / prevention & control* Pregnancy Recurrence |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Successful pregnancy in an ovarian agenesis patient after modified natural cycle IVF oocyte donation...
Next Document: Comparative genomic hybridization of oocytes and first polar bodies from young donors.